Microbiology Fundamentals: A Clinical Approach
3rd Edition
ISBN: 9781259709227
Author: Marjorie Kelly Cowan Professor, Heidi Smith
Publisher: McGraw-Hill Education
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Question
Chapter 18, Problem 11Q
Summary Introduction
To discuss:
Whether human genetics play a role in HIV infection and provide at least one example to illustrate the answer.
Introduction:
The HIV is the Human Immunodeficiency virus, which causes AIDS (Acquired Immunodeficiency syndrome). The HIV disrupts the ability of the body to fight against disease causing microorganisms.
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19. On the diagram below
a. Label the three pictures as: DNA; polypeptide; or RNA.
b. Label the arrows as: translation or transcription/RNA processing.
c. Add the following details to the diagram.
Promoter region
TATA box
Transcription start site
Transcription terminator
Intron (A,B,C,D)
Exons (1,2,3,4,5)
Splice sites
5' cap
5' UTR (untranslated region)
3' poly A tail
3' UTR (untranslated region)
Translational start (AUG)
Translational stop (UGA, UAG, or UAA)
N and C ends of polypeptide
0000
Match the letter labels in the figure below to the terms. Some letter
labels are not used.
MNNNNNNIN
M
C
B
A
M
D
F
E
H
K
G
8
The diagram below illustrates a quorum sensing pathway from Staphylococcus aureus. Please answer the following questions.
1. Autoinduction is part of the quorum sensing system. Which promoter (P2 or P3) is critical for autoinduction?
2)This staphylococcus aureus grows on human wounds, causing severe infections. You would like to start a clinical trial to treat these wound infections. Please describe:
a) What molecule do you recommend for the trial. Why?
b) Your trial requires that Staphylococcus aureus be isolated from the wound and submitted to genome sequencing before admittance. Why? What are you testing for?
3) If a mutation arises where the Promoter P3 is constitutively active, how would that influence sensitivity to AIP? Please explain your rationale.
4) This pathway is sensitive to bacterial cell density. Describe two separate mutation that would render the pathway active independent of cell density. Briefly explain your rationale.
Mutation 1
Mutation 2
Chapter 18 Solutions
Microbiology Fundamentals: A Clinical Approach
Ch. 18.1 - Describe the important anatomical features of the...Ch. 18.1 - List the natural defenses present in the...Ch. 18.1 - Prob. 1NPCh. 18.2 - Explain the what and the why of the normal biota...Ch. 18.3 - List the possible causative agents, modes of...Ch. 18.3 - Discuss the epidemiology of malaria.Ch. 18.3 - Prob. 6AYPCh. 18.3 - Discuss the important features of infectious...Ch. 18.3 - Prob. 8AYPCh. 18.3 - Prob. 9AYP
Ch. 18.3 - Prob. 10AYPCh. 18.3 - Prob. 11AYPCh. 18.3 - Prob. 2NPCh. 18.3 - Prob. 3NPCh. 18.3 - Prob. 1MMCh. 18.3 - Prob. 2MMCh. 18.3 - Prob. 4NPCh. 18.3 - Q. Look at the deadliness of Ebola in the feature...Ch. 18.3 - Prob. 5NPCh. 18 - Which of the following microbes have evolved an...Ch. 18 - Why do you think that malarial infection is more...Ch. 18 - In chapter 17 you were asked to speculate on why a...Ch. 18 - Which of the following is a G+ bacterium? a....Ch. 18 - What characteristic(s) of Bacillus anthracis make...Ch. 18 - Prob. 6QCh. 18 - Prob. 7QCh. 18 - Prob. 8QCh. 18 - Argue for the bloodstream being an advantageous...Ch. 18 - Prob. 10QCh. 18 - Prob. 11QCh. 18 - Use a unique characteristic of HIV to provide an...Ch. 18 - Prob. 13QCh. 18 - Prob. 14QCh. 18 - This text frequently discusses the increase in...Ch. 18 - Normal biota found in the oral cavity are most...Ch. 18 - Prob. 17QCh. 18 - For decades public health officials have been...Ch. 18 - Lyme disease is most likely to occur in a. North...Ch. 18 - Prob. 20QCh. 18 - When female mosquitoes mate with males infected...Ch. 18 - Prob. 1VC
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