EBK MICROBIOLOGY:W/DISEASES BY BODY...-
EBK MICROBIOLOGY:W/DISEASES BY BODY...-
5th Edition
ISBN: 9780134608242
Author: BAUMAN
Publisher: PEARSON
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Chapter 18, Problem 10CT

Reverse transcriptase is notoriously sloppy in making DNA copies from RNA templates. How do retroviruses survive when their genomes are subjected to such shoddy replication?

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The genome of a retrovirus can integrate into the host cell genome. What gene is unique to retroviruses, and why is the protein encoded by this gene absolutely necessary for maintaining the retroviral life cycle?
Some retroviruses that have a wide host range have been developed for use in treatment of diseases or syndromes. These viruses do not result in a productive infection because they lack critical genes for viral replication, but they do carry DNA sequences that allow them to be packaged into infectious particles. Once in the host cell the viral DNA is released and integrates into the cell's genome. The advantage to this strategy is that the delivery of the DNA is very efficient. What is one possible problem of using a virus that can integrate into the human nuclear genome? Multiple Choice The virus carries genes that will interfere with host cell activities. The viral DNA sequences could still cause a disease. Since the viral DNA sequences no longer contain essential genes for viral replication the host cell may not be able to replicate either. The integration could disrupt an essential gene or genes.
What enzyme is responsible for the production of viral DNA from a retrovirus?

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EBK MICROBIOLOGY:W/DISEASES BY BODY...-

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