Biology
12th Edition
ISBN: 9781260494570
Author: Raven, Peter
Publisher: MCGRAW-HILL HIGHER EDUCATION
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Textbook Question
Chapter 17.4, Problem 2LO
Compare and contrast knockout, knockin, and conditional knockout mice.
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Are double-knockout animals (DKOs) and even triple-knockoutanimals (TKOs) also possible ?
Explain why an investigator might want to create aconditional knockout mouse.
Explain the construction of knockout mice?
Chapter 17 Solutions
Biology
Ch. 17.1 - Prob. 1LOCh. 17.1 - Prob. 2LOCh. 17.1 - Describe the construction and uses of recombinant...Ch. 17.2 - Relate the process of DNA replication to PCR.Ch. 17.2 - Compare and contrast PCR, RT-PCR, and quantitative...Ch. 17.3 - Prob. 1LOCh. 17.3 - Prob. 2LOCh. 17.3 - Describe the pros and cons of RNA interference and...Ch. 17.4 - Explain how the universal nature of the genetic...Ch. 17.4 - Compare and contrast knockout, knockin, and...
Ch. 17.4 - Prob. 3LOCh. 17.5 - Describe the benefits of biofuel production from...Ch. 17.5 - Prob. 2LOCh. 17.5 - Prob. 3LOCh. 17.6 - Prob. 1LOCh. 17.6 - Compare and contrast FISH and gene chip...Ch. 17.6 - Describe how immunoassays can be used to diagnose...Ch. 17.7 - Describe the benefits of creating transgenic...Ch. 17.7 - Prob. 2LOCh. 17.7 - Evaluate issues on each side of the transgenic...Ch. 17 - Prob. 1DACh. 17 - Prob. 2DACh. 17 - Prob. 1IQCh. 17 - Prob. 2IQCh. 17 - You study a gene known to be important in the...Ch. 17 - What is the basis of separation of different DNA...Ch. 17 - Prob. 3UCh. 17 - FISH analysis of a breast tumor biopsy for HER2...Ch. 17 - In terms of studying gene function, what is the...Ch. 17 - The Ti plasmid of Agrobacterium usually induces...Ch. 17 - Prob. 1ACh. 17 - Which of the following statements is accurate for...Ch. 17 - Prob. 3ACh. 17 - Many human proteins, such as hemoglobin, are only...Ch. 17 - Amyloid beta is a proteolytic product of a protein...
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Name any two diseases for which transgenic mice are used as model organisms.arrow_forwardWhat is knockdown gene analysis? How is this different from knockout analysis?arrow_forwardWhat is a fluorophore? If you wanted to fluorescently label a brain cell, describe one way you could genetically label a brain cell using a transgenic approach and give one way you could genetically label a brain cell using a gene targeting homologous recombination approach.arrow_forward
- Describe how you would use replica plating of mutagenized, haploid yeast cells to identify temperature-sensitive (ts) mutations in essential genes needed for yeast growth and survival.arrow_forwardWhat is a simple way of making a knockout mouse in terms of DNA recombinant technology?arrow_forwardWith regard to TNRE, what is meant by the term anticipation?arrow_forward
- Compare and contrast the use of histochemical reporter genes and fluorescent reporter genes — what are the advantages and disadvantages of each?arrow_forwardDescribe the construction of knockout mice?arrow_forwardWhat is a molecular marker? Give two examples. Discuss why it isgenerally easier to locate and map molecular markers rather thanfunctional genes.arrow_forward
- What is double-knockout animals (DKOs) ?arrow_forwardDescribe the medical applications of human gene therapy in the following diseases: Haemophilia, Cystic fibrosis, and Leber congenital amaurosis.arrow_forwardA. In what year was the National Bioethics Advisory Council formed? B. The first mammal clone to be produced from an adult (somatic cell)?arrow_forward
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