EP ESSENTIAL ORG.CHEM.-MOD.MASTERING
3rd Edition
ISBN: 9780133858501
Author: Bruice
Publisher: PEARSON CO
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Textbook Question
Chapter 17, Problem 37P
- a. Why is the pKa of the glutamate side chain greater than the pKa of the aspartate side chain?
- b. Why is the pKa of the arginine side chain greater than the pKa of the lysine side chain?
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Students have asked these similar questions
Why is the side chain Pka of amino acid so much higher ?
Arginine has these pKa values: pka1 for the carboxyl group = 2.17, pKa2 for the amino group = 9.04, and pKaR for the side chain - 12.48
At pH 7, which groups in arginine are protonated?
amino and side chain
OB. none
Oc ll
OD. carboxyl and side chain
O E. side chain only
3. Pepsin cleavage of the peptide
Ala-His-Gly-Trp-Val-lle-Arg-Gly
would yield the peptides Ala-His-Gly-Trp and Val-Ile-Arg-Gly.
4. Argininosuccinate synthetase converts citrulline and aspartate into
argininosuccinate.
T F
T F
Chapter 17 Solutions
EP ESSENTIAL ORG.CHEM.-MOD.MASTERING
Ch. 17.1 - a. Explain why, when the imidazole ring of...Ch. 17.2 - Prob. 2PCh. 17.3 - Prob. 3PCh. 17.3 - Prob. 4PCh. 17.3 - Prob. 6PCh. 17.4 - Calculate the pI of each of the following amino...Ch. 17.4 - a. Which amino acid has the lowest pI value? b....Ch. 17.5 - What aldehyde is formed when valine is treated...Ch. 17.5 - Prob. 10PCh. 17.5 - Prob. 11P
Ch. 17.5 - Prob. 12PCh. 17.6 - Prob. 13PCh. 17.6 - What amino acid would be formed using the...Ch. 17.6 - What amino acid would be formed when the aldehyde...Ch. 17.7 - Pig liver esterase is an enzyme that catalyzes the...Ch. 17.8 - Prob. 17PCh. 17.8 - Prob. 18PCh. 17.8 - Prob. 19PCh. 17.8 - Prob. 20PCh. 17.10 - Prob. 21PCh. 17.10 - Prob. 22PCh. 17.10 - Why does cyanogen bromide not cleave on the C-side...Ch. 17.10 - Prob. 24PCh. 17.10 - Prob. 26PCh. 17.12 - Prob. 27PCh. 17.13 - a. Which would have the greatest percentage of...Ch. 17 - Draw the predominant form of the following amino...Ch. 17 - What is the pI of serine?Ch. 17 - Prob. 31PCh. 17 - Prob. 32PCh. 17 - Which would have a higher percentage of negative...Ch. 17 - Draw the form of aspartate that predominates at...Ch. 17 - Prob. 35PCh. 17 - A professor was preparing a manuscript for...Ch. 17 - a. Why is the pKa of the glutamate side chain...Ch. 17 - Prob. 38PCh. 17 - Determine the amino acid sequence of a polypeptide...Ch. 17 - Prob. 40PCh. 17 - Prob. 41PCh. 17 - Three peptides were obtained from a trypsin...Ch. 17 - Prob. 43PCh. 17 - After the polypeptide shown here was treated with...Ch. 17 - The disulfide bridges of a polypeptide were...Ch. 17 - -Amino acids can be prepared by treating an...Ch. 17 - Reaction of a polypeptide with carboxypeptidase A...Ch. 17 - Prob. 48PCh. 17 - Prob. 49PCh. 17 - Show how valine can be prepared by a. a Strecker...Ch. 17 - Prob. 51PCh. 17 - Why is proline never found in an -helix?Ch. 17 - Determine the amino acid sequence of a polypeptide...Ch. 17 - Prob. 55PCh. 17 - A chemist wanted to test his hypothesis that the...Ch. 17 - A normal polypeptide and a mutant of the...
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- You are called in as a consult for a patient who suffers from acidosis. Urine levels of both lactic acid and isocitric acid are elevated. Mitochondria isolated from the patient’s fibroblasts oxidize pyruvate very slowly whereas α-ketoglutarate and malate are oxidized normally. a. At what enzyme would you predict the patient has a defect? b. Why? What evidence do you have to choose that enzyme? c. How do you account for the increase in lactic acid?arrow_forwardArginine has these pKa values: pka1 for the carboxyl group = 2.17, pKa2 for the amino group = 9.04, and pKaR for the side chain - 12.48 At pH 7, which groups in arginine are protonated? amino and side chain O B. none Oç all OD. carboxyl and side chain side chain only OE.arrow_forward0 Can the product of a reaction that is part of a sequence act as an inhibitor for another reaction in the sequence? Explain.arrow_forward
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