The peptides obtained from the cleavage of given peptide chain by carboxypeptidase A has to be given. Concept introduction: Amino acids are linked each other by peptide bonds is called protein (one or more peptide bonds). Peptide bonds are amide bonds, in which carbonyl group of one amino acid bonded to amino group of other amino acid. The chain of the protein is drawn in such a way that left end is occupied by free amino group (say N-terminal) and right side of the chain is occupied by carbonyl group (say C-terminal). Exopeptidases cleave peptide bonds that are not at the end. Carboxypeptidase A is an exopeptidase, which cleave the peptide bond of C-terminal amino acid except arginine and lysine.

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Answer 1

Question

Chapter 17, Problem 32P

(a)

Interpretation Introduction

Interpretation:

The peptides obtained from the cleavage of given peptide chain by carboxypeptidase A has to be given.

Concept introduction:

Amino acids are linked each other by peptide bonds is called protein (one or more peptide bonds). Peptide bonds are amide bonds, in which carbonyl group of one amino acid bonded to amino group of other amino acid. The chain of the protein is drawn in such a way that left end is occupied by free amino group (say N-terminal) and right side of the chain is occupied by carbonyl group (say C-terminal).

Exopeptidases cleave peptide bonds that are not at the end.

Carboxypeptidase A is an exopeptidase, which cleave the peptide bond of C-terminal amino acid except arginine and lysine.

(b)

Interpretation Introduction

Interpretation:

The peptides obtained from the cleavage of given peptide chain by cyanogen bromide has to be given

Concept introduction:

Amino acids are linked each other by peptide bonds is called protein (one or more peptide bonds). Peptide bonds are amide bonds, in which carbonyl group of one amino acid bonded to amino group of other amino acid. The chain of the protein is drawn in such a way that left end is occupied by free amino group (say N-terminal) and right side of the chain is occupied by carbonyl group (say C-terminal).

Cyanogen bromide cleaves the C-terminal peptide of Methionine in a peptide chain.

(c)

Interpretation Introduction

Interpretation:

The peptides obtained from the cleavage of given peptide chain by trypsin has to be given.

Concept introduction:

Amino acids are linked each other by peptide bonds is called protein (one or more peptide bonds). Peptide bonds are amide bonds, in which carbonyl group of one amino acid bonded to amino group of other amino acid. The chain of the protein is drawn in such a way that left end is occupied by free amino group (say N-terminal) and right side of the chain is occupied by carbonyl group (say C-terminal).

Endopeptidases cleave peptide bonds that are not at the end.

Trypsin is an endopeptidase, which cleave the C-side peptide bond of positively charged side chains such as arginine and lysine.

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Which of the following reagents can be used to cleave a tert-butoxycarbonyl (Boc) protecting group from a peptide? H₂/Pd CF3CO₂H Na₂CO3, H₂O LiAlH4 B

3. Provide a synthetic route to each of the following compounds. a. H2N-gly-phe-ala-CO,H from the constituent aminoacids using a solid phase synthesis b. но N3 NH2 HO, N. from and anything else C. Alanine from glycine ČF3

N-(2-hydroxyethyl)piperazine-N'-(2-ethanesulfonic A purified protein is in a Hepes acid) buffer at pH 7 with 375 mM NaCl. A dialysis membrane tube holds a 2.0 mL sample of the protein solution. The sample tube floats in a beaker containing 1.00 L of the same Hepes buffer, but with 0 mM NaCl, for dialysis. Small molecules and ions (such as Na+, Cl, and Hepes) can to diffuse across the dialysis membrane, but the protein cannot. Assume there are no sample volume changes during the dialysis. Calculate the final concentration of NaCl in the protein sample once the dialysis has come to equilibrium. Calculate the final NaCl concentration in the 2.0 mL protein sample after dialysis in 150 mL of the same Hepes buffer, with 0 mM NaCl, twice in succession. [NaC1] after a single dialysis: [NaCl] after a double dialysis: x10' TOOLS mM mM

Answer 2

Question

Chapter 17, Problem 32P

(a)

Interpretation Introduction

Interpretation:

The peptides obtained from the cleavage of given peptide chain by carboxypeptidase A has to be given.

Concept introduction:

Amino acids are linked each other by peptide bonds is called protein (one or more peptide bonds). Peptide bonds are amide bonds, in which carbonyl group of one amino acid bonded to amino group of other amino acid. The chain of the protein is drawn in such a way that left end is occupied by free amino group (say N-terminal) and right side of the chain is occupied by carbonyl group (say C-terminal).

Exopeptidases cleave peptide bonds that are not at the end.

Carboxypeptidase A is an exopeptidase, which cleave the peptide bond of C-terminal amino acid except arginine and lysine.

(b)

Interpretation Introduction

Interpretation:

The peptides obtained from the cleavage of given peptide chain by cyanogen bromide has to be given

Concept introduction:

Amino acids are linked each other by peptide bonds is called protein (one or more peptide bonds). Peptide bonds are amide bonds, in which carbonyl group of one amino acid bonded to amino group of other amino acid. The chain of the protein is drawn in such a way that left end is occupied by free amino group (say N-terminal) and right side of the chain is occupied by carbonyl group (say C-terminal).

Cyanogen bromide cleaves the C-terminal peptide of Methionine in a peptide chain.

(c)

Interpretation Introduction

Interpretation:

The peptides obtained from the cleavage of given peptide chain by trypsin has to be given.

Concept introduction:

Amino acids are linked each other by peptide bonds is called protein (one or more peptide bonds). Peptide bonds are amide bonds, in which carbonyl group of one amino acid bonded to amino group of other amino acid. The chain of the protein is drawn in such a way that left end is occupied by free amino group (say N-terminal) and right side of the chain is occupied by carbonyl group (say C-terminal).

Endopeptidases cleave peptide bonds that are not at the end.

Trypsin is an endopeptidase, which cleave the C-side peptide bond of positively charged side chains such as arginine and lysine.

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Answer 3

Question

Chapter 17, Problem 32P

(a)

Interpretation Introduction

Interpretation:

The peptides obtained from the cleavage of given peptide chain by carboxypeptidase A has to be given.

Concept introduction:

Amino acids are linked each other by peptide bonds is called protein (one or more peptide bonds). Peptide bonds are amide bonds, in which carbonyl group of one amino acid bonded to amino group of other amino acid. The chain of the protein is drawn in such a way that left end is occupied by free amino group (say N-terminal) and right side of the chain is occupied by carbonyl group (say C-terminal).

Exopeptidases cleave peptide bonds that are not at the end.

Carboxypeptidase A is an exopeptidase, which cleave the peptide bond of C-terminal amino acid except arginine and lysine.

(b)

Interpretation Introduction

Interpretation:

The peptides obtained from the cleavage of given peptide chain by cyanogen bromide has to be given

Concept introduction:

Amino acids are linked each other by peptide bonds is called protein (one or more peptide bonds). Peptide bonds are amide bonds, in which carbonyl group of one amino acid bonded to amino group of other amino acid. The chain of the protein is drawn in such a way that left end is occupied by free amino group (say N-terminal) and right side of the chain is occupied by carbonyl group (say C-terminal).

Cyanogen bromide cleaves the C-terminal peptide of Methionine in a peptide chain.

(c)

Interpretation Introduction

Interpretation:

The peptides obtained from the cleavage of given peptide chain by trypsin has to be given.

Concept introduction:

Amino acids are linked each other by peptide bonds is called protein (one or more peptide bonds). Peptide bonds are amide bonds, in which carbonyl group of one amino acid bonded to amino group of other amino acid. The chain of the protein is drawn in such a way that left end is occupied by free amino group (say N-terminal) and right side of the chain is occupied by carbonyl group (say C-terminal).

Endopeptidases cleave peptide bonds that are not at the end.

Trypsin is an endopeptidase, which cleave the C-side peptide bond of positively charged side chains such as arginine and lysine.

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Answer 4

Question

Chapter 17, Problem 32P

(a)

Interpretation Introduction

Interpretation:

The peptides obtained from the cleavage of given peptide chain by carboxypeptidase A has to be given.

Concept introduction:

Amino acids are linked each other by peptide bonds is called protein (one or more peptide bonds). Peptide bonds are amide bonds, in which carbonyl group of one amino acid bonded to amino group of other amino acid. The chain of the protein is drawn in such a way that left end is occupied by free amino group (say N-terminal) and right side of the chain is occupied by carbonyl group (say C-terminal).

Exopeptidases cleave peptide bonds that are not at the end.

Carboxypeptidase A is an exopeptidase, which cleave the peptide bond of C-terminal amino acid except arginine and lysine.

(b)

Interpretation Introduction

Interpretation:

The peptides obtained from the cleavage of given peptide chain by cyanogen bromide has to be given

Concept introduction:

Amino acids are linked each other by peptide bonds is called protein (one or more peptide bonds). Peptide bonds are amide bonds, in which carbonyl group of one amino acid bonded to amino group of other amino acid. The chain of the protein is drawn in such a way that left end is occupied by free amino group (say N-terminal) and right side of the chain is occupied by carbonyl group (say C-terminal).

Cyanogen bromide cleaves the C-terminal peptide of Methionine in a peptide chain.

(c)

Interpretation Introduction

Interpretation:

The peptides obtained from the cleavage of given peptide chain by trypsin has to be given.

Concept introduction:

Amino acids are linked each other by peptide bonds is called protein (one or more peptide bonds). Peptide bonds are amide bonds, in which carbonyl group of one amino acid bonded to amino group of other amino acid. The chain of the protein is drawn in such a way that left end is occupied by free amino group (say N-terminal) and right side of the chain is occupied by carbonyl group (say C-terminal).

Endopeptidases cleave peptide bonds that are not at the end.

Trypsin is an endopeptidase, which cleave the C-side peptide bond of positively charged side chains such as arginine and lysine.

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Answer 5

Chapter 17, Problem 32P

(a)

Interpretation Introduction

Interpretation:

The peptides obtained from the cleavage of given peptide chain by carboxypeptidase A has to be given.

Concept introduction:

Amino acids are linked each other by peptide bonds is called protein (one or more peptide bonds). Peptide bonds are amide bonds, in which carbonyl group of one amino acid bonded to amino group of other amino acid. The chain of the protein is drawn in such a way that left end is occupied by free amino group (say N-terminal) and right side of the chain is occupied by carbonyl group (say C-terminal).

Exopeptidases cleave peptide bonds that are not at the end.

Carboxypeptidase A is an exopeptidase, which cleave the peptide bond of C-terminal amino acid except arginine and lysine.

(b)

Interpretation Introduction

Interpretation:

The peptides obtained from the cleavage of given peptide chain by cyanogen bromide has to be given

Concept introduction:

Amino acids are linked each other by peptide bonds is called protein (one or more peptide bonds). Peptide bonds are amide bonds, in which carbonyl group of one amino acid bonded to amino group of other amino acid. The chain of the protein is drawn in such a way that left end is occupied by free amino group (say N-terminal) and right side of the chain is occupied by carbonyl group (say C-terminal).

Cyanogen bromide cleaves the C-terminal peptide of Methionine in a peptide chain.

(c)

Interpretation Introduction

Interpretation:

The peptides obtained from the cleavage of given peptide chain by trypsin has to be given.

Concept introduction:

Amino acids are linked each other by peptide bonds is called protein (one or more peptide bonds). Peptide bonds are amide bonds, in which carbonyl group of one amino acid bonded to amino group of other amino acid. The chain of the protein is drawn in such a way that left end is occupied by free amino group (say N-terminal) and right side of the chain is occupied by carbonyl group (say C-terminal).

Endopeptidases cleave peptide bonds that are not at the end.

Trypsin is an endopeptidase, which cleave the C-side peptide bond of positively charged side chains such as arginine and lysine.

Answer 6

Chapter 17, Problem 32P

(a)

Interpretation Introduction

Interpretation:

The peptides obtained from the cleavage of given peptide chain by carboxypeptidase A has to be given.

Concept introduction:

Amino acids are linked each other by peptide bonds is called protein (one or more peptide bonds). Peptide bonds are amide bonds, in which carbonyl group of one amino acid bonded to amino group of other amino acid. The chain of the protein is drawn in such a way that left end is occupied by free amino group (say N-terminal) and right side of the chain is occupied by carbonyl group (say C-terminal).

Exopeptidases cleave peptide bonds that are not at the end.

Carboxypeptidase A is an exopeptidase, which cleave the peptide bond of C-terminal amino acid except arginine and lysine.

Answer 7

Chapter 17, Problem 32P

(a)

Interpretation Introduction

Interpretation:

The peptides obtained from the cleavage of given peptide chain by carboxypeptidase A has to be given.

Concept introduction:

Amino acids are linked each other by peptide bonds is called protein (one or more peptide bonds). Peptide bonds are amide bonds, in which carbonyl group of one amino acid bonded to amino group of other amino acid. The chain of the protein is drawn in such a way that left end is occupied by free amino group (say N-terminal) and right side of the chain is occupied by carbonyl group (say C-terminal).

Exopeptidases cleave peptide bonds that are not at the end.

Carboxypeptidase A is an exopeptidase, which cleave the peptide bond of C-terminal amino acid except arginine and lysine.

Answer 8

(b)

Interpretation Introduction

Interpretation:

The peptides obtained from the cleavage of given peptide chain by cyanogen bromide has to be given

Concept introduction:

Amino acids are linked each other by peptide bonds is called protein (one or more peptide bonds). Peptide bonds are amide bonds, in which carbonyl group of one amino acid bonded to amino group of other amino acid. The chain of the protein is drawn in such a way that left end is occupied by free amino group (say N-terminal) and right side of the chain is occupied by carbonyl group (say C-terminal).

Cyanogen bromide cleaves the C-terminal peptide of Methionine in a peptide chain.

Answer 9

(b)

Interpretation Introduction

Interpretation:

The peptides obtained from the cleavage of given peptide chain by cyanogen bromide has to be given

Concept introduction:

Amino acids are linked each other by peptide bonds is called protein (one or more peptide bonds). Peptide bonds are amide bonds, in which carbonyl group of one amino acid bonded to amino group of other amino acid. The chain of the protein is drawn in such a way that left end is occupied by free amino group (say N-terminal) and right side of the chain is occupied by carbonyl group (say C-terminal).

Cyanogen bromide cleaves the C-terminal peptide of Methionine in a peptide chain.

Answer 10

(c)

Interpretation Introduction

Interpretation:

The peptides obtained from the cleavage of given peptide chain by trypsin has to be given.

Concept introduction:

Amino acids are linked each other by peptide bonds is called protein (one or more peptide bonds). Peptide bonds are amide bonds, in which carbonyl group of one amino acid bonded to amino group of other amino acid. The chain of the protein is drawn in such a way that left end is occupied by free amino group (say N-terminal) and right side of the chain is occupied by carbonyl group (say C-terminal).

Endopeptidases cleave peptide bonds that are not at the end.

Trypsin is an endopeptidase, which cleave the C-side peptide bond of positively charged side chains such as arginine and lysine.

Answer 11

(c)

Interpretation Introduction

Interpretation:

The peptides obtained from the cleavage of given peptide chain by trypsin has to be given.

Concept introduction:

Amino acids are linked each other by peptide bonds is called protein (one or more peptide bonds). Peptide bonds are amide bonds, in which carbonyl group of one amino acid bonded to amino group of other amino acid. The chain of the protein is drawn in such a way that left end is occupied by free amino group (say N-terminal) and right side of the chain is occupied by carbonyl group (say C-terminal).

Endopeptidases cleave peptide bonds that are not at the end.

Trypsin is an endopeptidase, which cleave the C-side peptide bond of positively charged side chains such as arginine and lysine.

Answer 12

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Answer 13

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Answer 14

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Answer 15

Ch. 17.1 - a. Explain why, when the imidazole ring of...Ch. 17.2 - Prob. 2P Ch. 17.3 - Prob. 3P Ch. 17.3 - Prob. 4P Ch. 17.3 - Prob. 6P Ch. 17.4 - Calculate the pI of each of the following amino...Ch. 17.4 - a. Which amino acid has the lowest pI value? b....Ch. 17.5 - What aldehyde is formed when valine is treated...Ch. 17.5 - Prob. 10P Ch. 17.5 - Prob. 11P

Solution Summary: The author explains carboxypeptidase A cleaves the peptide bond of C-terminal amino acid except arginine and lysine.

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Chapter 17 Solutions