Life: The Science of Biology
Life: The Science of Biology
11th Edition
ISBN: 9781319010164
Author: David E. Sadava, David M. Hillis, H. Craig Heller, Sally D. Hacker
Publisher: W. H. Freeman
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Chapter 17, Problem 2Q
Summary Introduction

To review:

The dose levels for the individuals with AA genotypes compared to the individuals with GG genotype at single nucleotide polymorphisms (SNP) 5689.

Given:

In the given graph, the rate of metabolism and drug concentration after 12 hours of administration is correlated with different genotypes of SNP 5689.

Life: The Science of Biology, Chapter 17, Problem 2Q

Introduction:

The metabolism of drug is effective in people with genotype GG where drug concentration in blood is around 70. The drug concentration for the genotype AA is around 130. The concentration of drug in the blood for the AA and GG genotypes differs because of the difference in the rate of metabolism.

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