Explanation cAMP (cyclic adenosine monophosphate) is generated by adenylate cyclase from ATP (adenosine triphosphate). Its synthesis depends on the binding of hormones like epinephrine, TSH, and glucagon. Inactive PKA (cAMP-dependent protein kinase) is converted to its activated form by binding of cAMP. As a consequence of binding of cAMP, the activity of several enzymes gets modified through phosphorylation. cAMP completes amplification of the signals at the signal level and also at the catalytic levels...

Biochemistry, The Molecular Basis of Life, 6th Edition

6th Edition

ISBN: 9780190259204

Author: Trudy McKee, James R. McKee

Publisher: Oxford University Press

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Question

Chapter 16, Problem 3Q

Summary Introduction

To review:

The sequence of events occurring on the binding of epinephrine, which triggers the synthesis of cAMP and the reason behind the breaking down of cAMP rapidly.

Introduction:

There are certain hormones; the actions of which are mediated by another set of molecules known as the second messenger. Some of the second messengers include cAMP (cyclic adenosine monophosphate), cGMP (cyclic guanosine monophosphate), inositol-phospholipid system, and calcium ions.

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Chapter 16, Problem 2Q

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Chapter 16 Solutions

Biochemistry, The Molecular Basis of Life, 6th Edition

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Solution Summary: The author explains the sequence of events occurring on the binding of epinephrine, which triggers cAMP synthesis, and the reason behind its rapid breakdown.

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