Introduction to General, Organic and Biochemistry
Introduction to General, Organic and Biochemistry
12th Edition
ISBN: 9780357391594
Author: Frederick A. Bettelheim; William H. Brown; Mary K. Campbell
Publisher: Cengage Learning US
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Chapter 15, Problem 27P

16*32 Many tumors of the breast are correlated with estrogen levels in the body. Drugs that interfere with estrogen binding have antitumor activity and may even help prevent tumor occurrence. A widely used antiestrogen drug is tamoxifen.

Chapter 15, Problem 27P, 16*32 Many tumors of the breast are correlated with estrogen levels in the body. Drugs that

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  1. Name the functional groups in tamoxifen.

  • Classify the amino group in tamoxifen as primary, secondary, or tertiary.
  • How many stereoisomers are possible for tamoxifen?
  • (d, Would you expect tamoxifen to be soluble or insoluble in water? In blood?

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    Q7. a. Draw the line-bond structure of the major product for the following reaction, if a reaction occurs, assume monohalogenation. b. Calculate the product ratios using the following information (hint: use the number of hydrogens in each category present to calculate the ratios). Chlorination: 1° Reactivity=1 2° Reactivity=4 Heat + Cl2 3° Reactivity=5
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