Chapter 15, Problem 16CONQ

Summary Introduction

To analyze:

Referring to the locations of domains in the glucocorticoidreceptor relative to the amino- and carboxyl-terminal ends of the protein, make a drawing illustrating the binding of aglucocorticoid receptor dimer to the DNA. Label the amino and carboxyl ends, the hormone-binding domains, theDNA-binding domains, the dimerization domains, and the transactivationdomains.

Introduction:

In the function of glucocorticoid receptor, smaller domains like transactivation domain, DNA binding domain, and hormone binding domain play specific functional roles. For example, the carboxy terminal portion contains a domain that functions as a glucocorticoid binding site. The locations of domains in the glucocorticoid receptor relative to the amino and carboxyl terminal ends of the protein can be used to draw a hypothetical diagram of a glucocorticoid receptor dimer bound to the DNA.