Campbell Biology in Focus, Books a la Carte Edition; Modified Mastering Biology with Pearson eText - ValuePack Access Card - for Campbell Biology in Focus (2nd Edition)
2nd Edition
ISBN: 9780134433769
Author: Lisa A. Urry, Michael L. Cain, Steven A. Wasserman
Publisher: PEARSON
expand_more
expand_more
format_list_bulleted
Videos
Question
Chapter 14.5, Problem 2CC
Summary Introduction
To explain:
The gene expression in the individuals heterozygous for the sickle cell allele shows effects of the allele under some circumstances.
Introduction:
The sickle cell anemia is a genetic disorder. This occurs due to the mutation in the hemoglobin chain which results in the change of shape of hemoglobin. The hemoglobin gets sickle shape. Due to its sickle shape, the binding affinity of hemoglobin towards oxygen decreases.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
Define ‘gene’. What is an allele and loss-of-function alleles? What do these alleles tell us about normal gene function?
. Considering the yellow and green pea color phenotypes studied by Gregor Mendel:a. What is the biochemical function of the proteinthat is specified by the gene responsible for thepea color phenotype?b. A null allele of a gene is an allele that does notspecify any of the biochemical function that thegene normally provides. Of the two alleles Y and y,which is more likely to be a null allele?c. In terms of the underlying biochemistry, why is theY allele dominant to the y allele?d. Why are peas that are yy homozygotes green?e. The amount of the protein specified by a gene isroughly proportional to the number of functionalcopies of the gene carried by a cell or individual.What do the phenotypes of YY homozygotes, Yyheterozygotes, and yy homozygotes tell us aboutthe amount of the Sgr enzyme (the product of thepea color gene) needed to produce a yellow color?
. Figure 18-14 presents haplotype data for the G6PD genein a worldwide sample of people.a. Draw a haplotype network for these haplotypes.Label the branches on which each SNP occurs.b. Which of the haplotypes has the most connectionsto other haplotypes?c. On what continents is this haplotype found?d. Counting the number of SNPs along the branchesof your network, how many differences are therebetween haplotypes 1 and 12?
Chapter 14 Solutions
Campbell Biology in Focus, Books a la Carte Edition; Modified Mastering Biology with Pearson eText - ValuePack Access Card - for Campbell Biology in Focus (2nd Edition)
Ch. 14.1 - MAKE CONNECTIONS In a research article about...Ch. 14.1 - What polypeptide product would you expect from a...Ch. 14.1 - DRAW IT The template strand of a gene contains the...Ch. 14.2 - What is a promoter? Is it located at the upstream...Ch. 14.2 - What enables RNA polymerase to start transcribing...Ch. 14.2 - WHAT IF? Suppose X-rays caused a sequence change...Ch. 14.3 - Given that there are about 20,000 human genes, how...Ch. 14.3 - How is RNA splicing similar to how you would watch...Ch. 14.3 - WHAT IF? What would be the effect of treating...Ch. 14.4 - What two processes ensure that the correct amino...
Ch. 14.4 - Discuss the ways in which rRNA structure likely...Ch. 14.4 - Describe how a polypeptide to be secreted is...Ch. 14.4 - WHAT IF? DRAW IT Draw a tRNA with the anticodon...Ch. 14.5 - What happens when one nucleotide pair is lost from...Ch. 14.5 - Prob. 2CCCh. 14.5 - WHAT IF? DRAW IT The template strand of a gene...Ch. 14 - In eukaryotic cells, transcription cannot begin...Ch. 14 - Prob. 2TYUCh. 14 - The anticodon of a particular tRNA molecule is A....Ch. 14 - Prob. 4TYUCh. 14 - Which component is not directly involved in...Ch. 14 - Prob. 6TYUCh. 14 - Prob. 7TYUCh. 14 - Prob. 8TYUCh. 14 - Fill in the following table: Type of RNA Functions...Ch. 14 - SCIENTIFIC INQUIRY Knowing that the genetic code...Ch. 14 - Prob. 11TYUCh. 14 - FOCUS ON INFORMATION Evolution accounts for the...Ch. 14 - SYNTHESIZE YOUR KNOWLEDGE Some mutations result in...
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Discuss Concepts Many human diseases are caused by recessive alleles that are not expressed in heterozygotes. Some people think that eugenicsthe selective breeding of humans to eliminate undesirable genetic traitsprovides a way for us to rid our populations of such harmful alleles. Explain why eugenics cannot eliminate such genetic traits from human populations.arrow_forward1) using at least one named example discuss the implication of allelic heterogeneity in single gene disorder for the presentation and progession of the disorder and its treatment 2) discuss the importance of understanding epigenetics in improving people healtharrow_forwardGive typing answer with explanation and conclusionarrow_forward
- 20.TRC is a non mendelian trait. A.what is the mode of inheritance of total ridge count (TRC) in human? B. Give two factor that influence this TRC trait. C.if father has genotype of AaBbccdd and mother has a aaBbccDd .what is the genotype of the maximum and minimum TRC for their expected children?arrow_forwardGive only typing answer with explanation and conclusionarrow_forwardPlease answer fastarrow_forward
- helparrow_forwardFrequency 12% (0) Cross-over frequencies for some genes on a tomato plant: Use the following information to answer the next question. (S) a. C. 64% tall plant (D) and normal tomato (0) 21% Select one: d. normal leaf (M) and tall plant (D) normal leaf (M) and normal tomato 33% normal leaf (M) and simple inflorescence (S) The cross-over frequency between genes O and S is tall plant (D) and simple inflorescence 52% b. 29% Genes 31% 97% Cross-Over 6% Oarrow_forwardO Mutation-selection balance Suppose that one allele A₁ mutates to another allele A2 at some rate, μ. Suppose as well that A₁ is dominant over A2 such that A₁A1 and A₁A2 both have the same fitness, but that individuals that are homozygous recessive (A2A2) for the mutant allele A2 are less fit than the dominant genotype by some amount s, the selection coefficient. In this case, A2 mutant alleles come into the population at rate µ, and are removed from the population only when the show up in homozygous genotypes. The gory mathematical proof can be found in Box 7.8, which tells us that: O ■ Example: Suppose A₁ mutates to A2 at rate 0.005, but A₂A2 homozygous recessives are 50% less fit (s = 0.5) than either A₁A1 or A₁A2. What are the expected equilibrial abundances of A₁ and A2? μ = 0.005 S = 0.5 p* = 1-sqrt(µ/s) = 1-sqrt(0.005/0.5) = 0.9 = sqrt(µ/s) = sqrt(0.005/0.5) = 0.1 ● * p = = 1-sqrt(µ/s) q* = sqrt(μ/s) ● Question: Suppose A₁ mutates to A2 at rate 0.01, but A₂A2 homozygous…arrow_forward
- Suppose that you are studying the role of Protein B, which you believe plays a role in regulating PCD/Apoptosis in mice. You create two lines of mutant mice. One (bb) is homozygous for a loss-of-function allele of gene B. The other (Bb) is heterozygous, with one wild-type allele and one loss-of function allele. Initially you pay particular attention to two phenotypes of the resulting mice:(i) The morphology of their paws (see picture) (ii) The size of their brains & shape of their skulls. The bb mice have unusually large brains and unusual protrusions from their skulls. Based on these data, does it appear that Protein B, when present and active, favors or inhibits PCD/Apoptosis?Briefly explain your reasoning. The answer should address both the paw and brain/skull data.arrow_forwardSuppose that you are studying the role of Protein B, which you believe plays a role in regulating PCD/Apoptosis in mice. You create two lines of mutant mice. One (bb) is homozygous for a loss-of-function allele of gene B. The other (Bb) is heterozygous, with one wild-type allele and one loss-of function allele. Initially you pay particular attention to two phenotypes of the resulting mice:(i) The morphology of their paws (see picture)(ii) The size of their brains & shape of their skulls. The bb mice have unusually large brains and unusual protrusions from their skulls. Suggest one other aspect of mouse morphology or physiology that you might expect to be altered in the absence of Protein B. Briefly explain your reasoning. Also, based on the apparent effect of Protein B on the likelihood of PCD/Apoptosis, would you classify Protein B as the product of a proto-oncogene or of a tumor suppressor gene?arrow_forwardQ11. One of the two genes known to be mutated in cases of Hypokalemic periodic paralysis (which is inherited in an autosomal dominant pattern but known to affect males more often than females) is the calcium voltage-gated channel subunit alpha1 S (CACNA1S). What is known about the gene is recorded here: https://www.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000081248;r=1:201039512-201112451 Please navigate to the link above and ensure that you click to reveal the transcript table. Then use the information in the table to answer the following question. What is the NCBI accession number (including the version) of the RefSeq Match for the first transcript (CACNA1S-201)? Answer: NCBI accession number (including the version) of the RefSeq Match for the first transcript (CACNA1S-201) is ...arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
Biology: The Dynamic Science (MindTap Course List)BiologyISBN:9781305389892Author:Peter J. Russell, Paul E. Hertz, Beverly McMillanPublisher:Cengage Learning
Biology: The Dynamic Science (MindTap Course List)
Biology
ISBN:9781305389892
Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan
Publisher:Cengage Learning
Parasites: Protozoa (classification, structure, life cycle); Author: ATP;https://www.youtube.com/watch?v=V4iSB0_7opM;License: Standard youtube license