Campbell Biology (10th Edition)
10th Edition
ISBN: 9780321775658
Author: Jane B. Reece, Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Robert B. Jackson
Publisher: PEARSON
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Chapter 14.4, Problem 2CC
Summary Introduction
To explain: The change in the single amino acid in hemoglobin that results in the aggregation of hemoglobin in long fibers.
Concept introduction:
The primary structure of proteins is the linear sequence of amino acids. It determines the shape and the functional ability of the protein. A small change in the amino acid sequence can alter a protein’s shape and its functions.
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Chapter 14 Solutions
Campbell Biology (10th Edition)
Ch. 14.1 - DRAW IT Pea plants heterozygous for flower...Ch. 14.1 - WHAT IF? List all gametes that could be made by a...Ch. 14.1 - MAKE CONNECTIONS In some pea plant crosses, the...Ch. 14.2 - Prob. 1CCCh. 14.2 - Two organisms, with genotypcs BbDD and BBDd, are...Ch. 14.2 - WHAT IF? Three characters (flower color, seed...Ch. 14.3 - What two properties, one structural and one...Ch. 14.3 - If a man with type AB blood marries a woman with...Ch. 14.3 - WHAT IF? A rooster with gray feathers and a hen...Ch. 14.4 - Beth and Tom each have a sibling with cystic...
Ch. 14.4 - Prob. 2CCCh. 14.4 - Prob. 3CCCh. 14.4 - MAKE CONNECTIONS In Table 14.1, note the...Ch. 14 - When Mendel did crosses of true-breeding purple-...Ch. 14 - DRAW IT Redraw the Punnett Square on The right...Ch. 14 - Inheritance patterns are often more complex than...Ch. 14 - Both members of a couple know that they are...Ch. 14 - DRAW IT Two pea plants heterozygous for the...Ch. 14 - A man with type A blood marries a woman with type...Ch. 14 - A man has six fingers on each hand and six toes on...Ch. 14 - DRAW IT A pea plant heterozygous for inflated pods...Ch. 14 - Flower position, stem length, and seed shape are...Ch. 14 - Prob. 6TYUCh. 14 - The genotype of F1, individuals in a tetrahybrid...Ch. 14 - What is the probability that each of thc following...Ch. 14 - Prob. 9TYUCh. 14 - Prob. 10TYUCh. 14 - In tigers, a recessive allele of a particular gene...Ch. 14 - In maize (com) plants,a dominant allele I inhibits...Ch. 14 - The pedigree belowtraces the inheritance of...Ch. 14 - Imagine that you are a genetic counselor, and a...Ch. 14 - EVOLUTION CONNECTION Over the past half century,...Ch. 14 - SCIENTIFIC INQUIRY You are handed a mystery pea...Ch. 14 - Prob. 17TYUCh. 14 - SYNTHESIZE YOUR KNOWLEDGE Just for fun, imagine...
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- 8.arrow_forwardWhat qualitative effect would you expect each of the following to have onthe P50 of hemoglobin?(a) Increase in pH from 7.2 to 7.4(b) Increase in PCO2 from 20 to 40 mm Hg(c) Dissociation into monomer polypeptide chains(d) Decrease in 2,3-BPG concentration from 7 mM to 5 mM in red cells.arrow_forwardWhat is the molecular basis for the difference in the electrophoretic pattern between normal hemoglobin A and hemoglobin S?arrow_forward
- A mutation in the alpha globin gene that introduced one additional basic amino acid residue in the BPG binding pocket would: (select one) a) Eliminate Hb’s positive cooperativity. b) Decrease Hb’s O2 binding affinity. c) Increase Hb’s O2 binding affinity. d) Increase O2 binding in muscle and decrease it in lungs. e) Decrease O2 binding in muscle and increase it in lungs. f) It would have no effect on the adult form of Hb.arrow_forwardApproximate nH for each protein from its Hill plot. Which proteins exhibits a greater degree of positive cooperativity, normal hemoglobin or the mutant hemoglobin?arrow_forwardNeed help Explain the consequence of the following mutation on the function of the corresponding proteins. A) In hemoglobin, His HC3 mutates to Glu (account for all the interactions that HC3 makes). B) In Mb, His F8 mutates to Trp. C) In fetal hemoglobin, Ser 143 mutates to Asp. D) In a-keratin fibrils, 80% of Lys and Glu were replaced with Ala and leu, respectively.arrow_forward
- Hemoglobin from different species can have different numbers of subunits. Let's consider three hemoglobin molecules: n = 1, n = 4, and n = 8, where each subunit has an oxygen P50 = 30 torr. (Recall that Pso is essentially a Kp and that oxygen partial pressure (torr) is directly proportional to concentration.) Which molecule transports the most O2 between the lungs (pO2 = 100 torr) and peripheral tissues (pO2 = 30 torr)? Please justify your answer.arrow_forwardThe classic demonstration that cell plasma membranes are composed ofbilayers depends on the following kinds of data:• The membrane lipids from 4.74 x 109erythrocytes will form a monolayer of area 0.89 m2when spread on a water surface.• The surface of one erythrocyte is approximately 100 μm2in area. Show that these data can be accounted for only if the erythrocyte membrane is a bilayer.arrow_forwardThese are performance curves for two oxygen binding proteins. While we didn't go over the curves themselves in lecture, what are the axis labels? Myoglobin 0.8 0.6 V 0.4 0.2 I 0.0 25 50 1.0 Hemoglobin P50 = 26 torr 75 I 100 The y-axis is the fractional saturation of the protein by oxygen The x-axis is related to the concentration of oxygen to which the protein is exposed. The y-axis is the concentration of oxygen in the air. The x-axis is the fractional saturation of the protein by oxygenarrow_forward
- Give detailed Solution with explanation neededarrow_forwardApproximate P50 for myoglobin from its binding curve. Approximate P50 for normal hemoglobin and the hemoglobin mutant from the binding curve. At low pO2 (below 20 Torr), which binds O2 with greater affinity, normal hemoglobin or the hemoglobin mutant? At high pO2 (above 30 Torr), which binds O2 with greater affinity, normal hemoglobin or the hemoglobin mutant? Which protein, normal hemoglobin or the hemoglobin mutant, transports O2 more efficiently? Briefly explain your answer.arrow_forward13) Q13) The relative volume of red blood cells can be known by measuring the hematocrit (the ratio between the volume occupied by red blood cells to the total volume of blood). If the sample shown in the figure is obtained in a laboratory, what is the expected viscosity of the sample of blood? Note that represents the viscosity of blood plasma nserum 0% 100 90 80 70 60 50 40 30 20 10 0 2.17 nserum 2.6 nserum 45 nserum 55 nserum % 100 90 80 70 60 50 40 30 10arrow_forward
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