Concept explainers
(a)
Interpretation:
The concentrations of the hormones, yielding 50% of maximal binding is to be determined.
Concept introduction:
The first step of hormone’s signaling pathway is binding to a receptor present inside the cell or on the surface of the cell. Stability of the hormone-receptor complex is reflected by the affinity. Higher the affinity, stronger is the relation between the hormone and receptor.
(b)
Interpretation:
Hormone that shows the highest affinity for receptor is to be determined.
Concept introduction:
The first step of hormone’s signaling pathway is binding to a receptor present inside the cell or on the surface of the cell. Stability of the hormone-receptor complex is reflected by the affinity. Higher the affinity, stronger is the relation between the hormone and receptor.
(c)
Interpretation:
Relation between the binding affinity of the hormone-receptor complex and the ability of the hormone to enhance adenylate cyclase activity should be determined.
The mechanism of action of hormone-receptor complex is to be determined.
Concept introduction:
The first step of hormone’s signaling pathway is binding to a receptor present inside the cell or on the surface of the cell. Stability of the hormone-receptor complex is reflected by the affinity. Higher the affinity, stronger is the relation between the hormone and receptor.
(d)
Interpretation:
Experiments should be determined to check whether a Gas protein is a component of signal-transduction pathways.
Concept introduction:
The first step of hormone’s signaling pathway is binding to a receptor present inside the cell or on the surface of the cell. Stability of the hormone-receptor complex is reflected by the affinity. Higher the affinity, stronger is the relation between the hormone and receptor.
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