Biochemistry
Biochemistry
8th Edition
ISBN: 9781464126109
Author: Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr., Lubert Stryer
Publisher: W. H. Freeman
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Chapter 14, Problem 18P
Interpretation Introduction

Interpretation:

The Alternative strategy for targeting EGF signaling pathway for antitumor drug development is mentioned.

Concept introduction:

The EGFR stands for epidermal growth factor receptor. This is one of the most important signaling pathways. Its role is to check growth rate and proliferation in cells. This is known to be involved in development of cancer.

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Draw the predominant form of glutamic acid at pH = 8.4. The pKa of the side chain is 4.1. Include proper stereochemistry. HO H2N OH pH = 8.4
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