Chapter 14, Problem 14.35P

Interpretation Introduction

Interpretation:

A potential energy diagram for enzyme-catalyzed reaction needs to be determined.

Concept introduction:

Mechanism of enzyme catalyst reaction is as follows:

$\text{E+S}\underset{k_{-1}}{\overset{k_1}{\rightleftarrows }}\text{ES}$ ....... (1) Faster

$\text{ES}\stackrel{k_2}{\to }\text{E+P}$ ....... (2) Slower, rate-determining step

Here, E represents enzyme catalyzing the reaction, S is substrate, and P product of the reaction.

Energy changes that occur during a reaction can appear in a diagram called a potential energy diagram. A potential energy graph shows the adjustment in the potential energy of a reaction as reactants is changed over into products.