Chapter 14, Problem 14.24QP

When a folded protein in solution is heated to a high enough temperature, its polypeptide chain will unfold to become the denatured protein—a process known as “denaturation.” The temperature at which most of the protein unfolds is called the “melting” temperature. The melting temperature of a certain protein is found to be 63°C, and the enthalpy of denaturation is 510 kJ/mol. Estimate the entropy of denaturation, assuming that the denaturation is a single-step equilibrium process; that is, folded protein ⇄ denatured protein. The single polypeptide protein chain has 98 amino acids. Calculate the entropy of denaturation per ammo acid.