Foundations in Microbiology
10th Edition
ISBN: 9781259705212
Author: Kathleen Park Talaro, Barry Chess Instructor
Publisher: McGraw-Hill Education
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Chapter 13.L2, Problem 2VC
Observe the following maps (a)-(c) of three diseases. Determine which show endemic, sporadic, or epidemic pattern, and explain what features have helped you to make this decision.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 13 Solutions
Foundations in Microbiology
Ch. 13.1 - Describe some of the major interactions between...Ch. 13.1 - Prob. 2ELOCh. 13.1 - Discuss the characteristics of the normal...Ch. 13.1 - Briefly relate the sources and conditions that...Ch. 13.1 - Identify which bodily sites remain free of living...Ch. 13.1 - Prob. 6ELOCh. 13.1 - Prob. 1CYPCh. 13.1 - Prob. 2CYPCh. 13.1 - Prob. 3CYPCh. 13.1 - Prob. 4CYP
Ch. 13.1 - Prob. 5CYPCh. 13.1 - Differentiate between transient and resident...Ch. 13.1 - Explain the factors that cause variations in the...Ch. 13.2 - Review the main stages in the development of an...Ch. 13.2 - Prob. 8ELOCh. 13.2 - Prob. 9ELOCh. 13.2 - Prob. 10ELOCh. 13.2 - Prob. 11ELOCh. 13.2 - Identify and discuss invasive factors and...Ch. 13.2 - Prob. 13ELOCh. 13.2 - Explain several ways in which true pathogens...Ch. 13.2 - Distinguish between pathogenicity and virulence.Ch. 13.2 - Prob. 10CYPCh. 13.2 - Prob. 11CYPCh. 13.2 - Prob. 12CYPCh. 13.2 - Describe several components of pathogens that are...Ch. 13.2 - Prob. 14CYPCh. 13.2 - Prob. 15CYPCh. 13.2 - Define toxigenicity and summarize the main...Ch. 13.2 - Prob. 17CYPCh. 13.3 - Describe the clinical stages of infection.Ch. 13.3 - Use key terms to describe different patterns of...Ch. 13.3 - Prob. 16ELOCh. 13.3 - Prob. 17ELOCh. 13.3 - Explain what is happening during each stage of...Ch. 13.3 - Prob. 19CYPCh. 13.3 - Name some examples of infections and their portals...Ch. 13.3 - 21. Using terminology from this section's “Guide...Ch. 13.4 - Define epidemiology, and summarize the major goals...Ch. 13.4 - Prob. 19ELOCh. 13.4 - Prob. 20ELOCh. 13.4 - Prob. 21ELOCh. 13.4 - Prob. 22ELOCh. 13.4 - Prob. 23ELOCh. 13.4 - Prob. 22CYPCh. 13.4 - Prob. 23CYPCh. 13.4 - Prob. 24CYPCh. 13.4 - Prob. 25CYPCh. 13.4 - Prob. 26CYPCh. 13.4 - What is epidemiologically and medically important...Ch. 13.5 - Prob. 24ELOCh. 13.5 - Prob. 25ELOCh. 13.5 - Summarize the steps in Koch’s postulates, and...Ch. 13.5 - Prob. 27ELOCh. 13.5 - Prob. 28ELOCh. 13.5 - Prob. 28CYPCh. 13.5 - Prob. 29CYPCh. 13.5 - Prob. 30CYPCh. 13.5 - Prob. 31CYPCh. 13.5 - Prob. 32CYPCh. 13.5 - Outline the major factors involved in...Ch. 13.L1 - Prob. 1MCQCh. 13.L1 - Prob. 2MCQCh. 13.L1 - Prob. 3MCQCh. 13.L1 - Prob. 4MCQCh. 13.L1 - Prob. 5MCQCh. 13.L1 - Prob. 6MCQCh. 13.L1 - Prob. 7MCQCh. 13.L1 - The presence of a few bacteria in the blood is...Ch. 13.L1 - Prob. 9MCQCh. 13.L1 - A/an ______ is a passive animal transporter of...Ch. 13.L1 - Prob. 11MCQCh. 13.L1 - Prob. 12MCQCh. 13.L1 - Prob. 13MCQCh. 13.L1 - A positive antibody test for HIV would be a...Ch. 13.L1 - Prob. 15MCQCh. 13.L1 - Prob. 16MCQCh. 13.L1 - Prob. 1CSRCh. 13.L1 - Prob. 2CSRCh. 13.L1 - Prob. 3CSRCh. 13.L1 - Prob. 1WCCh. 13.L1 - Prob. 2WCCh. 13.L1 - Prob. 3WCCh. 13.L1 - Prob. 4WCCh. 13.L1 - Prob. 5WCCh. 13.L1 - Prob. 6WCCh. 13.L1 - Prob. 7WCCh. 13.L1 - a. Outline the five types of clinical isolation....Ch. 13.L1 - Complete the following table. Chemical makeup...Ch. 13.L2 - Discuss the relationship between the vaginal...Ch. 13.L2 - Prob. 2CTCh. 13.L2 - How could the microbiome cause some infections to...Ch. 13.L2 - Each of the nine patient specimens listed below...Ch. 13.L2 - Prob. 5CTCh. 13.L2 - Prob. 6CTCh. 13.L2 - Prob. 7CTCh. 13.L2 - a. Suggest several reasons why respiratory,...Ch. 13.L2 - Summarize the epidemiological findings in the...Ch. 13.L2 - Looking at figure 13.20b. Which pattern of...Ch. 13.L2 - Prob. 1VCCh. 13.L2 - Observe the following maps (a)-(c) of three...Ch. 13.L2 - Prob. 3VC
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