The parts of body that are constantly exposed and in contact with the external environment have residing normal microbiota white the internal organ, tissues, and the body fluids are sterile.

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Chapter 13.1, Problem 5CYP

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The parts of body that are constantly exposed and in contact with the external environment have residing normal microbiota white the internal organ, tissues, and the body fluids are sterile.

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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.

2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0 Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…

The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?

Answer 2

Question

Chapter 13.1, Problem 5CYP

Summary Introduction

Introduction:

The parts of body that are constantly exposed and in contact with the external environment have residing normal microbiota white the internal organ, tissues, and the body fluids are sterile.

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Answer 3

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Chapter 13.1, Problem 5CYP

Summary Introduction

Introduction:

The parts of body that are constantly exposed and in contact with the external environment have residing normal microbiota white the internal organ, tissues, and the body fluids are sterile.

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Answer 4

Question

Chapter 13.1, Problem 5CYP

Summary Introduction

Introduction:

The parts of body that are constantly exposed and in contact with the external environment have residing normal microbiota white the internal organ, tissues, and the body fluids are sterile.

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Answer 5

Chapter 13.1, Problem 5CYP

Summary Introduction

Introduction:

The parts of body that are constantly exposed and in contact with the external environment have residing normal microbiota white the internal organ, tissues, and the body fluids are sterile.

Answer 6

Chapter 13.1, Problem 5CYP

Summary Introduction

Introduction:

The parts of body that are constantly exposed and in contact with the external environment have residing normal microbiota white the internal organ, tissues, and the body fluids are sterile.

Answer 7

Chapter 13.1, Problem 5CYP

Summary Introduction

Introduction:

The parts of body that are constantly exposed and in contact with the external environment have residing normal microbiota white the internal organ, tissues, and the body fluids are sterile.

Answer 8

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Answer 11

Ch. 13.1 - Describe some of the major interactions between...Ch. 13.1 - Prob. 2ELO Ch. 13.1 - Discuss the characteristics of the normal...Ch. 13.1 - Briefly relate the sources and conditions that...Ch. 13.1 - Identify which bodily sites remain free of living...Ch. 13.1 - Prob. 6ELO Ch. 13.1 - Prob. 1CYP Ch. 13.1 - Prob. 2CYP Ch. 13.1 - Prob. 3CYP Ch. 13.1 - Prob. 4CYP

The parts of body that are constantly exposed and in contact with the external environment have residing normal microbiota white the internal organ, tissues, and the body fluids are sterile.

Solution Summary: The author explains that the internal organ, tissues, and body fluids are sterile, while the exposed organs harbor the normal microbiota.

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The parts of body that are constantly exposed and in contact with the external environment have residing normal microbiota white the internal organ, tissues, and the body fluids are sterile.

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Chapter 13 Solutions

The parts of body that are constantly exposed and in contact with the external environment have residing normal microbiota white the internal organ, tissues, and the body fluids are sterile.

Solution Summary: The author explains that the internal organ, tissues, and body fluids are sterile, while the exposed organs harbor the normal microbiota.

Concept explainers

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Introduction: The parts of body that are constantly exposed and in contact with the external environment have residing normal microbiota white the internal organ, tissues, and the body fluids are sterile.

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Chapter 13 Solutions

Introduction:

The parts of body that are constantly exposed and in contact with the external environment have residing normal microbiota white the internal organ, tissues, and the body fluids are sterile.