Anatomy & Physiology
3rd Edition
ISBN: 9781259398629
Author: McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher: Mcgraw Hill Education,
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Chapter 12.10, Problem 30WDL
Summary Introduction
To determine:
How acetylcholine generates either EPSP or an IPSP.
Concept introduction:
A neurotransmitter is chemical substances which are released by the axon terminals at the time of arrival of the nerve impulses. These neurotransmitters are stored in synaptic vesicles. These vesicles then fuse with the sending membrane which results in the release of neurotransmitter into the synaptic cleft.
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Which types of patch clamp technique should be used if you want to determine if a particular compound is influencing synaptic transmission presynaptically or post synaptically?
What are THREE major functional characteristics of the voltage-gate Na+-channels and how do these characteristics contribute to the generation of action potential?
Let’s say the synapses of a neuron’s dendrites are filled with glutamate-gated channels which, when activated by glutamate, cause an excitatory postsynaptic potential (EPSP) in the neuron. In one instance, glutamate is released at all of the synapses simultaneously and this leads to an action potential in the neuron.
A) What type of summation of PSPs is this? Why?
B) List the sequence of steps that occur starting from binding of glutamate to the glutamate-gated channels at the synapses and ending with the membrane potential at the axon hillock returning to resting potential at the end of the action potential. (Include all the changes in voltage-gated channels underlying the action potential.)
Chapter 12 Solutions
Anatomy & Physiology
Ch. 12.1 - Prob. 1LOCh. 12.1 - Prob. 1WDLCh. 12.1 - Prob. 2LOCh. 12.1 - Prob. 3LOCh. 12.1 - What are the two primary functional divisions of...Ch. 12.1 - Prob. 4LOCh. 12.1 - Prob. 5LOCh. 12.2 - What are the three connective tissue wrappings in...Ch. 12.2 - Prob. 6LOCh. 12.2 - Prob. 4WDL
Ch. 12.2 - Prob. 7LOCh. 12.2 - Prob. 8LOCh. 12.2 - Prob. 5WDLCh. 12.2 - LEARNING OBJECTIVE
9. Distinguish between fast...Ch. 12.2 - Prob. 6WDLCh. 12.2 - Prob. 10LOCh. 12.2 - Prob. 11LOCh. 12.2 - Prob. 7WDLCh. 12.2 - Prob. 8WDLCh. 12.3 - Prob. 12LOCh. 12.3 - Prob. 13LOCh. 12.3 - Prob. 9WDLCh. 12.4 - Prob. 14LOCh. 12.4 - If a person has a brain tumor, is it more likely...Ch. 12.4 - Prob. 15LOCh. 12.4 - Prob. 11WDLCh. 12.4 - Prob. 12WDLCh. 12.4 - Prob. 16LOCh. 12.4 - Prob. 17LOCh. 12.4 - Prob. 13WDLCh. 12.5 - Prob. 18LOCh. 12.5 - Prob. 19LOCh. 12.5 - Prob. 14WDLCh. 12.5 - Prob. 15WDLCh. 12.6 - LEARNING OBJECTIVE
20. Distinguish between a pump...Ch. 12.6 - Prob. 16WDLCh. 12.6 - Prob. 21LOCh. 12.6 - LEARNING OBJECTIVE
22. Identify and describe the...Ch. 12.6 - Prob. 17WDLCh. 12.7 - Prob. 23LOCh. 12.7 - Prob. 18WDLCh. 12.7 - Prob. 24LOCh. 12.7 - Prob. 25LOCh. 12.7 - Prob. 26LOCh. 12.7 - Prob. 19WDLCh. 12.7 - Prob. 20WDLCh. 12.8 - Prob. 27LOCh. 12.8 - LEARNING OBJECTIVE
28. Compare and contrast the...Ch. 12.8 - Prob. 29LOCh. 12.8 - Prob. 1WDTCh. 12.8 - How are EPSP and IPSP graded potentials...Ch. 12.8 - LEARNING OBJECTIVE
30. Define summation, and...Ch. 12.8 - Prob. 22WDLCh. 12.8 - Prob. 31LOCh. 12.8 - Prob. 32LOCh. 12.8 - Prob. 33LOCh. 12.8 - How does depolarization and repolarization occur...Ch. 12.8 - Prob. 24WDLCh. 12.8 - Prob. 34LOCh. 12.8 - Prob. 35LOCh. 12.8 - Prob. 25WDLCh. 12.9 - Prob. 36LOCh. 12.9 - Prob. 26WDLCh. 12.9 - Prob. 37LOCh. 12.9 - Prob. 38LOCh. 12.9 - Prob. 27WDLCh. 12.9 - Prob. 39LOCh. 12.9 - Prob. 28WDLCh. 12.10 - Prob. 40LOCh. 12.10 - Prob. 41LOCh. 12.10 - Prob. 29WDLCh. 12.10 - LEARNING OBJECTIVE
42. Describe how acetylcholine...Ch. 12.10 - Prob. 43LOCh. 12.10 - WHAT DO YOU THINK?
2 Predict the general effect of...Ch. 12.10 - Prob. 30WDLCh. 12.10 - Prob. 44LOCh. 12.10 - Prob. 45LOCh. 12.10 - Prob. 31WDLCh. 12.11 - LEARNING OBJECTIVE
46. Identify the four different...Ch. 12.11 - Prob. 32WDLCh. 12.11 - Prob. 33WDLCh. 12 - _____ 1. The cell body of a neuron does all of the...Ch. 12 - Prob. 2DYBCh. 12 - Prob. 3DYBCh. 12 - Prob. 4DYBCh. 12 - Prob. 5DYBCh. 12 - Prob. 6DYBCh. 12 - _____ 7. An action potential is generated when...Ch. 12 - Prob. 8DYBCh. 12 - Prob. 9DYBCh. 12 - Prob. 10DYBCh. 12 - What are the four structural types of neurons? How...Ch. 12 - Prob. 12DYBCh. 12 - How does myelination differ between the CNS and...Ch. 12 - Describe the procedure by which a PNS axon may...Ch. 12 - Prob. 15DYBCh. 12 - Prob. 16DYBCh. 12 - Explain summation of EPSPs and IPSPs and the...Ch. 12 - Graph and explain the events associated with an...Ch. 12 - Prob. 19DYBCh. 12 - Prob. 20DYBCh. 12 - Prob. 1CALCh. 12 - Prob. 2CALCh. 12 - Prob. 3CALCh. 12 - Prob. 4CALCh. 12 - Sarah wants to call her new friend Julie and needs...Ch. 12 - Over a period of 6 to 9 months, Marianne began to...Ch. 12 - Prob. 2CSLCh. 12 - Prob. 3CSL
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- When an impulse arrives at the synapse, the synaptic vesicles open and release neurotransmitters into the cleft within a thousandth of a second. Within another ten thousandth of a second, these molecules have diffused across the cleft and bound to receptor sites in the effector cell. In what two ways is transmission across a synapse terminated so that the neuron’s signal is concluded?arrow_forwardWhat are epsp’s and ipsp’s, where are they occurring and of what physiological importance are they?arrow_forwardWhat effect would you expect an antagonist that targets the voltage sensing domain of perisynaptic calcium channels of an inhibitory interneuron have on the firing frequency of a finically active neuron that interneuron synapses onto? Explain in detailsarrow_forward
- What type of synaptic potential (if any; be sure to indicate if any modification is occurring as well) would occur if: a.) An MAO inhibitor type of antidepressant is functioning at an active dopaminergic synapse that increases the rate of sodium flowing into the cell. b.) Prozac is present at an active serotonin synapse where receptor activation increases the flow of potassium out of the cell.arrow_forwardWhat is the approximate magnitude of the IPSP (how many mV)?What is the approximate magnitude of the EPSP (how many mV)?If the IPSP had not occurred, what would be the difference between the EPSP and the thresholdrequired to produce an action potential?arrow_forwardIn Neurology, please explain the relationship between suprathreshold depolarization and induced electrical neuro transmission. Is suprathreshold depolarization essential for inducing the electrical transmission?please explain in a few sentences.arrow_forward
- What is a typical value for an inhibitory post synaptic potential? Why is i inhibitory?arrow_forwardWhat is the role of calcium in neuronal communication at the axon terminal? What would be prevented if calcium channels could not open here in the terminal?arrow_forwardName the three phases of an action potential. Describe for each the underlying molecular basis and the ion involved. Why is the term voltage-gated channel applied to Na+ channels involved in the generation of an action potential?arrow_forward
- What ion/s is/are most likely to have a high conductance through the Jerrionin channel?arrow_forwardWhat does summation mean when we talk of postsynaptic potentials? When is summation non-linear?arrow_forwardPhotoreceptor cells form glutamatergic synapses onto bipolar cells and when photoreceptor cells are depolarized the release of glutamate into the synapse is increased. One class of bipolar cells, (called OFF bipolar cells) have excitatory glutamate receptors in their post-synaptic specialization. What happens to the membrane potential of OFF bipolar cells when photoreceptors are illuminated?arrow_forward
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