A.
To explain: How the Cl- channels help in acidification.
Introduction: Several cellular organelles are acidified by vacuolar H+-ATPase proton pumps that also function in the mitochondrial ATP synthesis. The electrogenic vacuolar H+-ATPase is responsible for generation of chemical and electrical gradients across the membrane. The vacuolar proton pump acidifies the inner part of the vesicle as well as provides a potential energy source for continuing a variety of coupled transporter. Acidification in the endosomal membrane is achieved by an H+ pump that contains chloride channels (Cl- channels).
B.
To explain: The Cl- channels will be absolutely needed to lower the pH inside the endosome.
Introduction: Several cellular organelles are acidified by vacuolar H+-ATPase proton pumps that also function in the mitochondrial ATP synthesis. The electrogenic vacuolar H+-ATPase is responsible for generation of chemical and electrical gradients across the membrane. The vacuolar proton pump acidifies the inner part of the vesicle as well as provides a potential energy source for continuing a variety of coupled transporter. Acidification in the endosomal membrane is achieved by an H+ pump that contains chloride channels (Cl- channels).
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Essential Cell Biology 5e
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