Pearson eText Fundamentals of General, Organic, and Biological Chemistry -- Instant Access (Pearson+)
8th Edition
ISBN: 9780135213759
Author: John McMurry, David Ballantine
Publisher: PEARSON+
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Textbook Question
Chapter 12, Problem 12.46AP
Which of the following pairs of structures are identical, which are isomers, and which are unrelated?
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Arrange the four structures in order from most reduced to most oxidized.
Most reduced
R-CH2-CH3
R-CH2-CH₂-OH
R-CH,-CHO
R-CH₂-COO
Most oxidized
for each pair of biomolecules, identify the type of reaction (oxidation-reduction, hydrolysis, isomerization, group transfer, or
nternal rearrangement) required to convert the first molecule to the second. In each case, indicate the general type of enzyme
and cofactor(s) c reactants required, and any other products that would result.
R-CH-CH-CH-C-S-COA
A(n)
A(n)
A(n)
A(n)
Palmitoyl-CoA
R-CH-CH=CH-C-S-CoA
°
trans-A-Enoyl-CoA
reaction converts palmitoyl-CoA to trans-A2-enoyl-CoA. This reaction requires
and also produces
Coo
HN-C-H
CH₂
CH₂
CH
CH
CH, CH,
L-Leucine
CH, CH,
D-Leucine
8/6881
COO
HÌNH:
reaction converts L-leucine to D-leucine. This reaction is catalyzed by a(n)
H-C-OH
H-C-OH
C=0
HO-C-H
HO-C-H
H-C-OH
H-C-OH
H-C-OH
CH,OH
Glucose
H-C-OH
CH,OH
Fructose
OH OH OH
CH-C-CH₂
reaction converts glucose to fructose. This reaction is catalyzed by a(n)
OH
OH OPO
I
CH-C-CH
H
Glycerol
Glycerol 3-phosphate
H
reaction converts glycerol to glycerol 3-phosphate. This reaction requires
H,N-
H,N
H…
After adding a small amount of ATP labeled with radioactive phosphorus in the terminal position, [7-32P]ATP, to a yeast extract,
a researcher finds about half of the 32P activity in P; within a few minutes, but the concentration of ATP remains unchanged. She
then carries out the same experiment using ATP labeled with 32P in the central position, [ẞ-³2P]ATP, but the 32P does not appear
in P; within such a short time.
Which statements explain these results?
Yeast cells reincorporate P; released from [ß-³2P]ATP into ATP more quickly than P¡ released from [y-³2P]ATP.
Only the terminal (y) phosphorous atom acts as an electrophilic target for nucleophilic attack.
The terminal (y) phosphoryl group undergoes a more rapid turnover than the central (B) phosphate group.
Yeast cells maintain ATP levels by regulating the synthesis and breakdown of ATP.
Correct Answer
Chapter 12 Solutions
Pearson eText Fundamentals of General, Organic, and Biological Chemistry -- Instant Access (Pearson+)
Ch. 12.2 - Locate and identify the functional groups in (a)...Ch. 12.2 - Draw structures for molecules that fit the...Ch. 12.3 - Prob. 12.3PCh. 12.3 - There are two branched-chain isomers with the...Ch. 12.4 - Draw the following three isomers of C5H12 as...Ch. 12.4 - Prob. 12.6PCh. 12.4 - Prob. 12.7PCh. 12.4 - Draw both condensed and line structures for the...Ch. 12.5 - Which of the following structures represent the...Ch. 12.5 - Are the pairs of compounds shown below the same...
Ch. 12.6 - Identify each carbon in the molecule shown in...Ch. 12.6 - Prob. 12.12PCh. 12.6 - Prob. 12.13PCh. 12.6 - Draw and name alkanes that meet the following...Ch. 12.6 - Prob. 12.15KCPCh. 12.6 - Prob. 12.1CIAPCh. 12.6 - Prob. 12.2CIAPCh. 12.6 - Prob. 12.3CIAPCh. 12.8 - Prob. 12.1MRPCh. 12.8 - Prob. 12.2MRPCh. 12.8 - Prob. 12.16PCh. 12.8 - Write the structures of all singly chlorinated...Ch. 12.10 - Prob. 12.18PCh. 12.10 - Prob. 12.19PCh. 12.10 - What is wrong with the following names? It will be...Ch. 12.10 - Prob. 12.21KCPCh. 12.10 - Prob. 12.4CIAPCh. 12.10 - (a) What common produce items might you see...Ch. 12 - Convert the following models into line drawings...Ch. 12 - Prob. 12.23UKCCh. 12 - Prob. 12.24UKCCh. 12 - Give the IUPAC names for the following...Ch. 12 - Prob. 12.26UKCCh. 12 - What characteristics of carbon make possible the...Ch. 12 - Prob. 12.28APCh. 12 - Prob. 12.29APCh. 12 - Prob. 12.30APCh. 12 - For each of the following, give an example of a...Ch. 12 - Identify the highlighted functional groups in the...Ch. 12 - Identify the functional groups in the following...Ch. 12 - Propose structures for molecules that fit the...Ch. 12 - Prob. 12.35APCh. 12 - What requirement must be met for two compounds to...Ch. 12 - Prob. 12.37APCh. 12 - Prob. 12.38APCh. 12 - Prob. 12.39APCh. 12 - Prob. 12.40APCh. 12 - Give an example of a compound that meets the...Ch. 12 - (a)There are two isomers with the formula C4H10....Ch. 12 - Write condensed structures for the following...Ch. 12 - Prob. 12.44APCh. 12 - Prob. 12.45APCh. 12 - Which of the following pairs of structures are...Ch. 12 - Prob. 12.47APCh. 12 - Prob. 12.48APCh. 12 - Prob. 12.49APCh. 12 - What are the IUPAC names of the following alkanes?Ch. 12 - Prob. 12.51APCh. 12 - Write condensed structures for the following...Ch. 12 - Draw line structures for the following...Ch. 12 - Name the following cycloalkanes:Ch. 12 - Prob. 12.55APCh. 12 - Prob. 12.56APCh. 12 - Prob. 12.57APCh. 12 - Prob. 12.58APCh. 12 - Prob. 12.59APCh. 12 - Prob. 12.60APCh. 12 - Prob. 12.61APCh. 12 - Write the formulas of the four singly chlorinated...Ch. 12 - Write the formulas of the three doubly brominated...Ch. 12 - Identify the indicated functional groups in the...Ch. 12 - The line structure for pregabalin (Lyrica) is...Ch. 12 - Prob. 12.66CPCh. 12 - Prob. 12.67CPCh. 12 - Most lipsticks are about 70% castor oil and wax....Ch. 12 - Prob. 12.69CPCh. 12 - Prob. 12.70CPCh. 12 - Prob. 12.71CPCh. 12 - Which of the following structures represent the...
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- Compare the structure of the nucleoside triphosphate CTP with the structure of ATP. NH₂ 0- 0- 0- ·P—O—P—O—P—O—CH₂ H H H H OH OH Cytidine triphosphate (CTP) Consider the reaction: ATP + CDP ADP + CTP NH 0- 0- 0- ¯0— P—O— P—O—P-O-CH₂ H Η о H H OH OH Adenosine triphosphate (ATP) NH₂ Now predict the approximate K'eq for this reaction. Now predict the approximate AG for this reaction. Narrow_forwardThe standard free energy, AGO, of hydrolysis of inorganic polyphosphate, polyP, is about −20 kJ/mol for each P; released. In a cell, it takes about 50 kJ/mol of energy to synthesize ATP from ADP and Pi. ○ P O Inorganic polyphosphate (polyP) Is it feasible for a cell to use polyP to synthesize ATP from ADP? Why or why not? No. The reaction is unidirectional and always proceeds in the direction of polyP synthesis from ATP. Yes. If [ADP] and [polyP] are kept high, and [ATP] is kept low, the actual free-energy change would be negative. No. The synthesis of ATP from ADP and P; has a large positive G'o compared to polyP hydrolysis. Yes. The hydrolysis of polyP has a sufficiently negative AG to overcome the positive AGO of ATP synthesis. Correct Answerarrow_forwardIn the glycolytic pathway, a six-carbon sugar (fructose 1,6-bisphosphate) is cleaved to form two three-carbon sugars, which undergo further metabolism. In this pathway, an isomerization of glucose 6-phosphate to fructose 6-phosphate (as shown in the diagram) occurs two steps before the cleavage reaction. The intervening step is phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate. H H | H-C-OH H-C-OH C=0 HO-C-H HO-C-H phosphohexose isomerase H-C-OH H-C-OH H-C-OH H-C-OH CH₂OPO CH₂OPO Glucose 6-phosphate Fructose 6-phosphate What does the isomerization step accomplish from a chemical perspective? Isomerization alters the molecular formula of the compound, allowing for subsequent phosphorylation. Isomerization moves the carbonyl group, setting up a cleavage between the central carbons. Isomerization causes the gain of electrons, allowing for the eventual release of NADH. Isomerization reactions cause the direct production of energy in the form of ATP.arrow_forward
- From data in the table, calculate the AG value for the reactions. Reaction AG' (kJ/mol) Phosphocreatine + H₂O →>> creatine + P -43.0 ADP + Pi → ATP + H₂O +30.5 Fructose +P → fructose 6-phosphate + H₂O +15.9 Phosphocreatine + ADP creatine + ATP AG'O ATP + fructose → ADP + fructose 6-phosphate AG'° kJ/mol kJ/molarrow_forwardMacmillan Learning The phosphorylation of glucose to glucose 6-phosphate is the initial step in the catabolism of glucose. The direct phosphorylation of glucose by P, is described by the equation Glucose + P ← glucose 6-phosphate + H₂O AG = 13.8 kJ/mol Coupling ATP hydrolysis to glucose phosphorylation makes thermodynamic sense, but consider how the coupling might take place. Given that coupling requires a common intermediate, one conceivable mechanism is to use ATP hydrolysis to raise the intracellular concentration of Pi. The increase in P; concentration would drive the unfavorable phosphorylation of glucose by Pi- Is increasing the P; concentration a reasonable way to couple ATP hydrolysis and glucose phosphorylation? No. The phosphate salts of divalent cations would be present in excess and precipitate out. Yes. Increasing the concentration of P; would decrease K'eq and shift equilibrium to the right. Yes. The extra ATP hydrolysis would provide enough free energy to drive the…arrow_forwardThe phosphorylation of glucose to glucose 6-phosphate is the initial step in the catabolism of glucose. The direct phosphorylation of glucose by P, is described by the equation Glucose + P → glucose 6-phosphate + H₂O AG' = 13.8 kJ/mol In principle, at least, one way to increase the concentration of glucose 6-phosphate (G6P) is to drive the equilibrium reaction to the right by increasing the intracellular concentrations of glucose and Pj. The maximum solubility of glucose is less than 1 M, and the normal physiological concentration of G6P is 250 μM. Assume a fixed concentration of P, at 4.8 mM. The calculated value of K'cq is 4.74 × 10-³ M-¹. Calculate the intracellular concentration of glucose when the equilibrium concentration of glucose 6-phosphate is 250 μM, the normal physiological concentration. [glucose] = 10.99 Correct Answer Would increasing the concentration of glucose be a physiologically reasonable way to increase the concentration of G6P? No. Because the concentration of P,…arrow_forward
- Calculate the equilibrium constant for the phosphorylation of glucose to glucose 6-phosphate at 37.0 °C. K'eq = M-' In the rat hepatocyte, the physiological concentrations of glucose and P, are maintained at approximately 4.8 mM. What is the equilibrium concentration of glucose 6-phosphate (G6P) obtained by the direct phosphorylation of glucose by P.? [G6P] = Does this reaction represent a reasonable metabolic step for the catabolism of glucose? Why or why not? Yes, because the value of AG" is positive. No, because the K'eq is too large for the reaction to proceed in the forward direction. Yes, because AG is negative at the calculated value of K'eq No, because [G6P] is likely to be higher than the calculated value. Marrow_forwardThe pKa values for glutamic acid are 2.19, 9.67, 4.25. Sketch out the titration curve for this amino acid and include all of the pKa values and the pl.arrow_forwardCalculate the isoelectronic point, pl, from the pKa values for histidine, arginine and asparagine.arrow_forward
- The free energy released by the hydrolysis of ATP under standard conditions is -30.5 kJ/mol. If ATP is hydrolyzed under standard conditions except at pH 5.0, is more or less free energy released? Why? More free energy is released because the increased [H+] stabilizes the negative charge on the ADP molecule. Less free energy is released because an acidic environment depletes cellular ATP levels. Less free energy is released because the reaction favors ATP production over hydrolysis due to the higher [H+] in solution. More free energy is released because the total cellular concentrations of ATP, ADP, and P; are greater at the lower pH. Correct Answerarrow_forwardConsider a system consisting of an egg in an incubator. The white and yolk of the egg contain proteins, carbohydrates, and lipids. If fertilized, the egg transforms from a single cell to a complex organism. How does the entropy change in both the system (developing chick) and suroundings (the egg environment) drive the irreversible process of chick development? ☐ The release of glucose from sucrose, which produces energy needed for chick development, decreases entropy in the surroundings. Chick development increases entropy in the system, which causes a concominant decrease in entropy in the surroundings. Carbohydrates, proteins, and lipids within the egg break down into CO2 and H2O, which increases entropy in the surroundings. Chick development decreases entropy in the system, but this is smaller than the concominant increase in entropy in the surroundings.arrow_forwardThe amino acid glycine is often used as the main ingredient of a buffer in biochemical experiments. The amino group of glycine, which has a pKa of 9.6, can exist either in the protonated form -NH or as the free base -NH2, because of the reversible equilibrium R-NH =R-NH₂ + H+ In what pH range can glycine be used as an effective buffer due to its amino group? pH 8.6 to pH 10.6 In a 0.1 M solution of glycine at pH 9.0, what fraction of glycine has its amino group in the -NH form? Correct Answer Correct Answer 45 How much 5 M KOH must be added to 1.0 L of 0.1 M glycine at pH 9.0 to bring its pH to 10.0? 10 mL When 99% of the glycine is in its -NH form, what is the numerical relation between the pH of the solution and the pKa of the amino group? pH = pKa - 2 Correct Answer Correct Answerarrow_forward
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