Human Anatomy
5th Edition
ISBN: 9780073403700
Author: Kenneth S. Saladin Dr.
Publisher: McGraw-Hill Education
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Chapter 12, Problem 12.2.3AYLO
The tensor fasciae latae of the hip and its relationship to the fibrous fascia lata and iliotibial tract of the lateral thigh (table12.6)
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 12 Solutions
Human Anatomy
Ch. 12.2 - Prob. 1AWYKCh. 12.2 - Prob. 2AWYKCh. 12.2 - Prob. 1BYGOCh. 12.2 - Prob. 2BYGOCh. 12.2 - Prob. 3BYGOCh. 12.2 - Prob. 4BYGOCh. 12.2 - Prob. 5BYGOCh. 12.2 - Prob. 6BYGOCh. 12.2 - Not everyone has the same muscles. From the...Ch. 12.2 - Prob. 7BYGO
Ch. 12.2 - Name the muscles that cross both the hip and knee...Ch. 12.2 - Prob. 9BYGOCh. 12.2 - Prob. 10BYGOCh. 12.2 - Prob. 11BYGOCh. 12.2 - Prob. 12BYGOCh. 12 - Prob. 12.1.1AYLOCh. 12 - Prob. 12.1.2AYLOCh. 12 - Prob. 12.1.3AYLOCh. 12 - Prob. 12.1.4AYLOCh. 12 - Prob. 12.1.5AYLOCh. 12 - Prob. 12.1.6AYLOCh. 12 - Prob. 12.1.7AYLOCh. 12 - Prob. 12.1.8AYLOCh. 12 - Prob. 12.1.9AYLOCh. 12 - Prob. 12.1.10AYLOCh. 12 - Prob. 12.1.11AYLOCh. 12 - Prob. 12.1.12AYLOCh. 12 - Prob. 12.1.13AYLOCh. 12 - Prob. 12.1.14AYLOCh. 12 - Prob. 12.1.15AYLOCh. 12 - Prob. 12.1.16AYLOCh. 12 - Prob. 12.2.1AYLOCh. 12 - The three gluteal muscles-gluteus maximus, gluteus...Ch. 12 - The tensor fasciae latae of the hip and its...Ch. 12 - Prob. 12.2.4AYLOCh. 12 - Prob. 12.2.5AYLOCh. 12 - Prob. 12.2.6AYLOCh. 12 - Prob. 12.2.7AYLOCh. 12 - The hamstring muscles of the posterior compartment...Ch. 12 - Prob. 12.2.9AYLOCh. 12 - Prob. 12.2.10AYLOCh. 12 - Prob. 12.2.11AYLOCh. 12 - Prob. 12.2.12AYLOCh. 12 - Prob. 12.2.13AYLOCh. 12 - Prob. 12.2.14AYLOCh. 12 - Prob. 12.2.15AYLOCh. 12 - Prob. 12.3.1AYLOCh. 12 - Prob. 12.3.2AYLOCh. 12 - Prob. 1TYRCh. 12 - Prob. 2TYRCh. 12 - Prob. 3TYRCh. 12 - Prob. 4TYRCh. 12 - Which of these muscles does not contribute to the...Ch. 12 - Which of these actions is not performed by the...Ch. 12 - Prob. 7TYRCh. 12 - Prob. 8TYRCh. 12 - Both the gastrocnemius and ____________ muscles...Ch. 12 - Prob. 10TYRCh. 12 - Prob. 11TYRCh. 12 - Prob. 12TYRCh. 12 - Pronation of the forearm is achieved by two...Ch. 12 - Prob. 14TYRCh. 12 - Prob. 15TYRCh. 12 - Prob. 16TYRCh. 12 - Prob. 17TYRCh. 12 - Prob. 18TYRCh. 12 - Prob. 19TYRCh. 12 - Prob. 20TYRCh. 12 - Prob. 1BYMVCh. 12 - Prob. 2BYMVCh. 12 - State a meaning of each world element and give a...Ch. 12 - Prob. 4BYMVCh. 12 - Prob. 5BYMVCh. 12 - Prob. 6BYMVCh. 12 - State a meaning of each world element and give a...Ch. 12 - Prob. 8BYMVCh. 12 - Prob. 9BYMVCh. 12 - Prob. 10BYMVCh. 12 - Briefly explain why each of the following...Ch. 12 - Determine which five of the following statements...Ch. 12 - Prob. 3TOFCh. 12 - Determine which five of the following statements...Ch. 12 - Prob. 5TOFCh. 12 - Prob. 6TOFCh. 12 - Briefly explain why each of the following...Ch. 12 - Prob. 8TOFCh. 12 - Prob. 9TOFCh. 12 - Prob. 10TOFCh. 12 - Prob. 1TYCCh. 12 - Prob. 2TYCCh. 12 - Poorly conditioned middle-aged people may suffer a...Ch. 12 - Women who habitually wear high heels may suffer...Ch. 12 - A student moving out of a dormitory crouches in...
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