Campbell Biology (10th Edition)
10th Edition
ISBN: 9780321775658
Author: Jane B. Reece, Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Robert B. Jackson
Publisher: PEARSON
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Textbook Question
Chapter 11, Problem 7TYU
Protein phosphorylation is commonly involved with all of the following except
- (A) activation of receptor tyrosine kinases.
- (B) activation of protein kinase moleculcs.
- (C) activation of G protein-coupled receptors.
- (D) regulation of transcription by signaling molecules.
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1) Amino acids that contain hydroxyl groups in their R-groups can be phosphorylated during cellular signaling.
(a) What amino acids can be phosphorylated? (use the one letter amino acid abbreviations)
(b) Does phosphorylation turn a signaling protein “on” or “off”?
(c) Whatis the most common source of a phosphate used to phosphorylate a protein
(d) What enzyme type (or category of enzymes)removes phosphates from proteins?
Signaling by tyrosine kinase receptors is generally associated with all of the following
except:
A) receptor dimerization
B) growth factor responses
C) heterotrimeric G proteins
D) cross phosphorylation
E) generating protein binding sites due to phosphorylation
Cellular signaling follows a cascade of events and has multiple points of regulation. Which of the following could be a reason(s) why a signalling cascade is interrupted, or turned 'off', once it has been turned 'on'?
A) a protein gets tagged with an ubiqutin group and gets degraded
B) a chemical modification occurred on serine, threonine, or tyrosine side chains to turn on/off proteins
C) allosteric regulation causes an active site to be hidden
D) All of the other answers are correct
E) The ligand is prevented from reaching the binding site
Chapter 11 Solutions
Campbell Biology (10th Edition)
Ch. 11.1 - Explain how signaling is involved in ensuring that...Ch. 11.1 - In liver cells, glycogen Phosphorylase acts in...Ch. 11.1 - Prob. 3CCCh. 11.2 - Nerve growth factor (NGF) is a water-soluble...Ch. 11.2 - WHAT IF? What would the effect be if a cell made...Ch. 11.2 - MAKE CONNECTIONS How is ligand binding similar to...Ch. 11.2 - Prob. 4CCCh. 11.3 - What is a protein kinase, and what is its role in...Ch. 11.3 - When a signal transduction pathway involves a...Ch. 11.3 - What is the actual signal that is being transduced...
Ch. 11.3 - WHAT IF? If you exposed a cell to a ligand that...Ch. 11.4 - How can a targct cell's response to a single...Ch. 11.4 - WHAT IF? If two cells have different scaffolding...Ch. 11.4 - Prob. 3CCCh. 11.5 - Give an example of apoptosis during embryonic...Ch. 11.5 - WH AT IF? If apoptosis occurred when it should...Ch. 11 - What determines whether a cell responds to a...Ch. 11 - How are the structures of a GPCR and an RTK...Ch. 11 - What is the difference between a protein kinase...Ch. 11 - What mechanisms in the cell terminale its response...Ch. 11 - What is an explanation for the similarities...Ch. 11 - Binding of a signaling molecule to which type of...Ch. 11 - The activation of receptor tyrosinc kinases is...Ch. 11 - Lipid-soluble signaling molecules, such as...Ch. 11 - Consider this pathway: epinephrine G...Ch. 11 - Apoptosis involves all but which of the following?...Ch. 11 - Which Observation suggestcd to Sutherland the...Ch. 11 - Protein phosphorylation is commonly involved with...Ch. 11 - DRAW IT Draw the following apoptotic pathway,...Ch. 11 - EVOLUTION CONNECTION Identify the evolutlonary...Ch. 11 - Prob. 10TYUCh. 11 - SCIENCE, TECHNOLOGY, AND SOCIETY The aging process...Ch. 11 - WRITE ABOUT A THEME: ORGANIZATION The properties...Ch. 11 - SYNTHESIZE YOUR KNOWLEDGE There are five basic...
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- Signaling by tyrosine kinase receptors is generally associated with all of the following except: OA) receptor dimerization B) growth factor responses C) heterotrimeric G proteins OD) cross phosphorylation E) generating protein binding sites due to phosphorylationarrow_forwardReceptor tyrosine kinases such as the epidermal growth factor (EGF) receptor can basically be broken down into three domains: (1) An extracellular, ligand binding domain, (2) A transmembrane domain that must cross through the cell membrane, and (3) an intracellular domain. Match the amino acid with the domain that it would MOST LIKELY be associated with. Lysine (choose (1), (2), or (3) from above) A tyrosine residue capable of being phosphorylated on its hydroxyl group (choose (1), (2), or (3) from above) Isoleucine (choose (1), (2), or (3) from above)arrow_forwardWith protein kinase-mediated molecular switches, downstream target molecules are typically activated by ... a) being phosphorylated b) binding to ATP c) the action of a phosphataase d) hydrolysis of GTP e) binding to GTParrow_forward
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- A) Please explain what a G protein coupled receptor is. Please explain how G protein interacts with this receptor. B) Please explain the kind of reactions that follow binding a specific ligand to a G protein coupled receptor. What do these reactions do in the cell? C) How do these reactions work in the cell. What is the function of these reactions in the cell? How do the reactions proceed?arrow_forwardWhen the inhibitory Ga (Gia) protein is mutated and increases its intrinsic GTPase activity, a) Adenylate cyclase become more active b) Gia becomes more active c) Both a and b d) Neither a or barrow_forwardActivation of certain GPCRs triggers an intracellular signaling mechanism that involves activation of adenlyl cyclase and an increase of cAMP. Which of the following statements best describes the the events that follow such a cAMP increase? a.) The cAMP increase leads to activation of protein kinase C. b.) The cAMP increase leads to activation of the release of the gamma subunit from the GPCR. c.) The cAMP increase leads to activation of protein kinase A.arrow_forward
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