To tell: Why physicians do not invariably prescribe the antimicrobial with the largest zone of inhibition. Introduction: The disk-diffusion test is a method applied to evaluate the antibiotic susceptibility. In petri plate (where an antibiotic disk is placed on a uniformly inoculated test pathogen), the clear area (measured in diameter) showing the absence of bacterial growth is referred to as the zone of inhibition. The minimal inhibitory concentration (MIC) is the least antibiotic concentration required to inhibit visible growth of bacteria. The minimal bactericidal concentration (MBC) is the lowest concentration of antibiotic required to kill the bacteria. But, it cannot be used to determine whether an antibiotic is bactericidal or just bacteriostatic. In order to determine MIC and MBC of an antibacterial drug, a broth dilution test is useful.

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Chapter 10, Problem 3TMW

Summary Introduction

To tell:

Why physicians do not invariably prescribe the antimicrobial with the largest zone of inhibition.

Introduction:

The disk-diffusion test is a method applied to evaluate the antibiotic susceptibility. In petri plate (where an antibiotic disk is placed on a uniformly inoculated test pathogen), the clear area (measured in diameter) showing the absence of bacterial growth is referred to as the zone of inhibition. The minimal inhibitory concentration (MIC) is the least antibiotic concentration required to inhibit visible growth of bacteria. The minimal bactericidal concentration (MBC) is the lowest concentration of antibiotic required to kill the bacteria. But, it cannot be used to determine whether an antibiotic is bactericidal or just bacteriostatic. In order to determine MIC and MBC of an antibacterial drug, a broth dilution test is useful.

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