Biology 2e
2nd Edition
ISBN: 9781947172517
Author: Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher: OpenStax
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Textbook Question
Chapter 10, Problem 35CTQ
What cell-cycle events will be affected in a cell that produces mutated (non-functional) cohesin protein?
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Describe the general conditions that must be met at each of the three main cell-cycle checkpoints.
(Q) During M-phase of cell cycle, active M-Cdk phosphorylates several target proteins in order to regulate their activities. Identify TWO specific examples of such target proteins that are phosphorylated by active M-Cdk, and explain how each of them affects the cell (i.e. their respective biological significance).
i) target protein phosphorylated: _______________________________
Biological Significance:
ii) target protein phosphorylated: _______________________________
Biological Significance:
Which important phenomenon is both inspected during g1 and g2 checkpoints of the cell cycle?
Chapter 10 Solutions
Biology 2e
Ch. 10 - Figure 10.6 Which of the following is the correct...Ch. 10 - Figure 10.13 Rb and other proteins that negatively...Ch. 10 - Figure 10.14 Human papillomavirus can cause...Ch. 10 - A diploid cell has ________ the number of...Ch. 10 - An organism s traits are determined by the...Ch. 10 - The first level of DNA organization in a...Ch. 10 - Identical copies of chromatin held together by...Ch. 10 - S. Chromosomes are duplicated during what stage of...Ch. 10 - Which of the following events does not occur...Ch. 10 - The mitotic spindles arise from which cell...
Ch. 10 - Attachment of the mitotic spindle fibers to the...Ch. 10 - Unpacking of chromosomes and the formation of a...Ch. 10 - Separation of the sister chromatids is a...Ch. 10 - The chromosomes become visible under a light...Ch. 10 - The fusing of Golgi vesicles at the metaplhase...Ch. 10 - At which of the cell-cycle checkpoints do external...Ch. 10 - What is the main prerequisite for clearance at the...Ch. 10 - If the M checkpoint is not cleared, what stage of...Ch. 10 - Which protein is a positive regulator that...Ch. 10 - Many of the negative regulator proteins of the...Ch. 10 - Which negative regulatory molecule can trigger...Ch. 10 - are changes to the order of nucleotides in a...Ch. 10 - A gene that codes for a positive cell-cycle...Ch. 10 - A mutated gene that codes for an altered version...Ch. 10 - Which molecule is a Cdk inhibitor that is...Ch. 10 - Which eukaryotic cell-cycle event is missing in...Ch. 10 - FtsZ proteins direct the formation of a...Ch. 10 - Compare and contrast a human somatic cell to a...Ch. 10 - What is the relationship between a genome,...Ch. 10 - Eukaryotic chromosomes are thousands of times...Ch. 10 - Briefly describe the events that occur in each...Ch. 10 - Chemotherapy drugs such as vincristine (derived...Ch. 10 - Describe the similarities and differences between...Ch. 10 - List some reasons why a cell that has just...Ch. 10 - What cell-cycle events will be affected in a cell...Ch. 10 - Describe the general conditions that must be met...Ch. 10 - Compare and contrast the roles of the positive...Ch. 10 - What steps are necessary for Cdk to become fully...Ch. 10 - Rb is a negative regulator that blocks the cell...Ch. 10 - Outline the steps that lead to a cell becoming...Ch. 10 - Explain the difference between a proto-oncogene...Ch. 10 - List the regulatory mechanisms that might be lost...Ch. 10 - ______ can trigger apoptosis if certain cell-cycle...Ch. 10 - Name the common components of eukaryotic cell...Ch. 10 - Describe how the duplicated bacterial chromosomes...
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- What aspects of the cell cycle are controlled by the G1, G2, and M checkpoints? How are cyclins and cyclin-dependent protein kinases involved in cell cycle regulation at checkpoints?arrow_forward"Agent V" is the name of an anticancer (chemotherapy) drug. This drug works against cancer cells by inhibiting the formation of microtubules in sensitive cells. Consider a cell that is sensitive to agent V (in other words, agent V is effective at stopping growth of this cell). Based on this information, agent V would cause the cell to be frozen at which of the major cell cycle checkpoints (G1, G2 or M checkpoint)? Explain your answer in 2- 4 sentences.arrow_forwardName at least one type of external stimulus that promotes re-entry of the cell cycle from G0 to G1 and signals to pass through the G1/S checkpoint.arrow_forward
- What are cell cycle checkpoints? Where in the cell cycle are the checkpoints found (note—incude S phase checkpoint? How do they differ? How are Rb, p53, and MPF involved in cell cycle checkpoints? What events could lead to cell cycle arrest?arrow_forwardThe Rb protein has been called the “master brake” of the cell cycle. Describe how the Rb protein acts as a cell cycle brake. How is the brake released in mid- to late G1 to allow the cell to proceed to S phase?arrow_forwardHow does MPF allow a cell to pass the G2 phase checkpointand enter mitosis? (See Figure 12.16.)arrow_forward
- During cell division cycle, cells need to monitor the process of DNA replication and segregation of replicated DNA so that these processes are error-free. Some potential errors that could occur include incomplete DNA replication, DNA damage in genome, and uneven separation of replicated genome. These mechanisms that cells used to monitor these processes are referred as the "cell cycle checkpoint, which can control specific Cdk activity to regulate the progression of cell cycle. For the following checkpoint mechanisms, indicate which Cdk activity is attenuated? Also indicate one of the key proteins or protein complexes involved in the following checkpoints. a) DNA damage checkpoint during S-phase b) Mitotic checkpoint during M-phasearrow_forwardWhat role do tumor suppressors, including p53, play in mediating cell cycle arrest for cells with DNA damage?arrow_forwardThe cell cycle is typically thought of as having four stages. Describe the stages of the cell cycle and identify the mechanism(s) involved in progressing or not progressing through the stages with reference to proteins and signalling processes involved. Please keep brief - 10 sentences/dot points max.arrow_forward
- Describe the three most important cell cycle checkpoints. Explain in a detailed manner and provide some sample scenarios.arrow_forwardA set of HeLa cells is being considered for an experiment. When these cells are analyzed using a machine that sorts cells according to the amount of DNA they contain, the graph below is obtained. Which peak, A or B, most likely represents cells in G1 phase?arrow_forwardWhat are the four phases of the cell cycle? What is the principal activity in the cell during each phase? Can any phase be eliminated or bypassed?arrow_forward
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