Biology 2e
2nd Edition
ISBN: 9781947172517
Author: Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher: OpenStax
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Textbook Question
Chapter 10, Problem 25RQ
Which molecule is a Cdk inhibitor that is controlled by p53?
- cyclin
- anti-kinase
- Rb
- p21
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Students have asked these similar questions
Which of the following types of mutations would be most likely to cause cells to undergo apoptosis (programmed cell death)?
One that increases the affinity of p21 for Cdks
One that decreases the affinity of Rb for the transcription factor E2F
One that decreases the ability of p53 to bind to DNA
One that causes p53 to be constitutively phosphorylated
please help
Which change is most likely to directly interfere with cytokinesis in a dividing animal cell?
The loss of a lysine residue in a histone protein
A mutation that affects the G2-M cyclin-CDK complex
A mutation in the gene that encodes actin
A mutation that affects the S cyclin-CDK complex
A mutation in the RB gene
Chapter 10 Solutions
Biology 2e
Ch. 10 - Figure 10.6 Which of the following is the correct...Ch. 10 - Figure 10.13 Rb and other proteins that negatively...Ch. 10 - Figure 10.14 Human papillomavirus can cause...Ch. 10 - A diploid cell has ________ the number of...Ch. 10 - An organism s traits are determined by the...Ch. 10 - The first level of DNA organization in a...Ch. 10 - Identical copies of chromatin held together by...Ch. 10 - S. Chromosomes are duplicated during what stage of...Ch. 10 - Which of the following events does not occur...Ch. 10 - The mitotic spindles arise from which cell...
Ch. 10 - Attachment of the mitotic spindle fibers to the...Ch. 10 - Unpacking of chromosomes and the formation of a...Ch. 10 - Separation of the sister chromatids is a...Ch. 10 - The chromosomes become visible under a light...Ch. 10 - The fusing of Golgi vesicles at the metaplhase...Ch. 10 - At which of the cell-cycle checkpoints do external...Ch. 10 - What is the main prerequisite for clearance at the...Ch. 10 - If the M checkpoint is not cleared, what stage of...Ch. 10 - Which protein is a positive regulator that...Ch. 10 - Many of the negative regulator proteins of the...Ch. 10 - Which negative regulatory molecule can trigger...Ch. 10 - are changes to the order of nucleotides in a...Ch. 10 - A gene that codes for a positive cell-cycle...Ch. 10 - A mutated gene that codes for an altered version...Ch. 10 - Which molecule is a Cdk inhibitor that is...Ch. 10 - Which eukaryotic cell-cycle event is missing in...Ch. 10 - FtsZ proteins direct the formation of a...Ch. 10 - Compare and contrast a human somatic cell to a...Ch. 10 - What is the relationship between a genome,...Ch. 10 - Eukaryotic chromosomes are thousands of times...Ch. 10 - Briefly describe the events that occur in each...Ch. 10 - Chemotherapy drugs such as vincristine (derived...Ch. 10 - Describe the similarities and differences between...Ch. 10 - List some reasons why a cell that has just...Ch. 10 - What cell-cycle events will be affected in a cell...Ch. 10 - Describe the general conditions that must be met...Ch. 10 - Compare and contrast the roles of the positive...Ch. 10 - What steps are necessary for Cdk to become fully...Ch. 10 - Rb is a negative regulator that blocks the cell...Ch. 10 - Outline the steps that lead to a cell becoming...Ch. 10 - Explain the difference between a proto-oncogene...Ch. 10 - List the regulatory mechanisms that might be lost...Ch. 10 - ______ can trigger apoptosis if certain cell-cycle...Ch. 10 - Name the common components of eukaryotic cell...Ch. 10 - Describe how the duplicated bacterial chromosomes...
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- Which of the following would result in cell cycle arrest? O phosphorylation of Rb by G1-Cdk phosphorylation of p53 O phosphorylation of helicase by S-Cdk phosphorylation of M-Cdk by CAK phosphorylation of APC by M-Cdkarrow_forwardWhich of the following could be classified as an oncogene? None are possible oncogenes A mutant of MAP kinase that was active with or without being phosphorylated All are possible oncogenes A mutant of MEK with significantly reduced enzyme activity A mutant cAMP phosphodiesterase that made it super-activearrow_forwardB. Cyclin-dependent Kinase 1. What are the proteins that determine the forward momentum of the cell cycle? 2. What essential nutrient (aside from protein) is needed so that the cycle may grow or develop? 3. What do you infer, in what conditions will the cell may advance the cell cycle? Explain briefly. CDK Activity G₁ G₁ Checkpoint The cyclin-CDK system checks for favorable environmental conditions and damaged DNA. DNA Replication Checkpoint The cyclin-CDK system checks for stalled replication machinery and damaged DNA. Time G₂ G₂ Checkpoint The cyclin-CDK system checks for unreplicated or damaged DNA. Metaphase Checkpoint The cyclin-CDK system checks that all chromo- somes are attached to spindle microtubules.arrow_forward
- If a cell cannot make any Rb protein, how will this affect the function of E2F?arrow_forward// Which CDK and cyclin does p53 ultimately target in DNA damaged conditions? O CDK1/cyclin E O CDK2/cyclin E CDK1/cyclin B CDK2/cyclin Barrow_forwardHow does p53 halt cell cycle progression when DNA damage is identified? p53 enhances expression of cyclins p53 stimulates the ubiquitination of cyclins p53 inhibits Wee1 p53 activates Cdc25 p53 enhances expression of the p21 inhibitorarrow_forward
- In attempting to design a drug that will impede cell cycle progression in ovarian cancers cells. you will want the drug to have this effect on the cells; Group of answer choices Increase expression of CDK7 Increase the phosphorylation of the ATP-binding pocket of CDK1 Increase expression of CDC25A All of thesearrow_forwardWhat would be the effect on the cell cycle if a cell acquired a mutation that rendered each of the following domains inactive? Explain your reasoning. The PSTAIR region of an M-phase Cdk The Wee1 Kinase The kinase that normally phosphorylates Sic 1 The Sic1 cyclin-Cdk inhibitorarrow_forward// Which one of these does CDK1/cyclin mitotic kinase NOT do to induce mitosis? Phosphorylates Histone H1 to condense chromosomes Phosphorylates pore proteins to disassemble pores Phosphorylates transcription factors to shut off transcription Phosphorylates lamins for lamin assemblyarrow_forward
- A gene that codes for a positive cell cycle regulator is called a(n) _______. a. kinase inhibitor b. tumor suppressor gene c. proto-oncogene d. oncogenearrow_forwardFigure 9.8 HER2 is a receptor tyrosine kinase. In 30 percent of human breast cancers, HER2 is permanently activated, resulting in unregulated cell division. Lapatinib, a drug used to treat breast cancer, inhibits HER2 receptor tyrosine kinase autophosphorylation (the process by which the receptor adds phosphates onto itself), thus reducing tumor growth by 50 percent. Besides autophosphorylation, which of the following steps would be inhibited by Lapatinib? Signaling molecule binding, dimerization, and the downstream cellular response. Dimerization, and the downstream cellular response. The downstream cellular response. Phosphatase activity, dimerization, and the downsteam cellular response.arrow_forwardA mutated gene that codes for an altered version of Cdk that is active in the absence of cyclin is a(n) ___________ . kinase inhibitor tumor suppressor gene proto-oncogene oncogene.arrow_forward
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