Genetics: From Genes to Genomes
Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
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Chapter 1, Problem 3P

The size of one copy of the human genome is approximately 3 billion base pairs, and it contains about 27,000 genes organized into 23 chromosomes.

a. Human chromosomes vary in size. What would you predict is the size of the
average chromosome?
b. Assuming that genes are spread evenly among chromosomes, how many genes
does an average human chromosome contain?
c. About half of the DNA in chromosome contains genes. How large (in base pairs)
is an average human gene?
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A typical eukaryotic chromosome found in humans has about 100 million bp of DNA. As noted in Chapter 11, 1 DNA base pair has a linear length of 0.34 nm.A. What is the linear length of the DNA in a typical human chromosomein micrometers?B. What is the linear length of a 30-nm fiber of a typical humanchromosome?C. Based on your calculation in part B, would a typical human chromosome fit inside the nucleus (with a diameter of 5 μm) if the 30-nm fiber were stretched out in a linear manner? If not, explain how a typical human chromosome fits inside the nucleus during interphase.
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