Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
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Chapter 1, Problem 15P
Mutations in genes that change their pattern of expression (the time and cell type in which the gene product is produced) are thought to be a major factor in the evolution of different organisms. Would you expect the same protein to work in the same way (for example, to perform the same kind of enzymatic reaction) in two different types of cells (for example, cells in the retina of the eye and muscle cells)? Is it possible that the same protein might function in different biochemical pathways in eye cells and muscle cells even if the protein’s basic mechanism always remains the same?
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In humans, the AMY1 gene produces the enzyme amylase in cells of the salivary glands. Amylase breaks down starch (a polysaccharide) into the sugar maltose (a disaccharide). People from cultures with diets high in starch produce more amylase than people from cultures with diets low in starch because of a mutation in the AMY1 gene. Explain in two to three sentences why the frequency of this AMY1 mutation would have increased in frequency in populations with a high starch diet.
Domestic dogs are closely related to wolves. Wolves have one copy of the gene that encodes the enzyme amylase. Amylase is required to digest starch. Dogs have between 4 and 30 copies of this gene. Explain how the new copies arose in the genome of the domestic dog. Compare this to the evolution of lactase persistence in humans. Explain how the diet and environment of a dog compared to a wolf would result in fixation of the duplicated gene. What possible explanation is there for the variation of copy number among dog breeds?
Many aspects of gene function can be nicely explained with the one-gene-one-enzyme hypothesis, which states that a gene controls the production of an enzyme. Which of the following findings about gene expression, though, requires an expansion of this simple concept?
Choose an answer below:
Non-enzyme proteins are made from genes too.
Some genes code for RNA molecules only.
Enzymes composed of different polypeptides are coded for by more than one gene.
a and c, but not b
a, b, and c
Chapter 1 Solutions
Genetics: From Genes to Genomes
Ch. 1 - Choose the phrase from the right column that best...Ch. 1 - If one strand of a DNA molecule has the base...Ch. 1 - The size of one copy of the human genome is...Ch. 1 - Indicate whether each of the following words or...Ch. 1 - a. How many different DNA strands composed of 100...Ch. 1 - RNA shares with proteins the ability to fold into...Ch. 1 - The human protein lactate dehydrogenase shown in...Ch. 1 - a. Are the triplets in the genetic code table...Ch. 1 - Why do scientists think that all forms of life on...Ch. 1 - Why would a geneticist study a yeast cell or a...
Ch. 1 - How can a scientist tell if a protein present in...Ch. 1 - Figure 1.6 shows the amino acid sequences of parts...Ch. 1 - Why do scientists think that new genes arise by...Ch. 1 - Explain how the exon/intron structure of genes...Ch. 1 - Mutations in genes that change their pattern of...Ch. 1 - A single zebrafish gene function was inactivated...Ch. 1 - Different mutations in the WDR62 gene that...Ch. 1 - Researchers have successfully used gene therapy to...Ch. 1 - By the time this book is published, it will likely...
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- You are studying a protein called Fatransformase that affects the saturation of phospholipds in plasma membranes in different species of frogs. You notice that in Froggus goofus and Froggus croakus that the Fatransformase is not active at cold temperatures (below 10oC). Upon closer inspection, you see that each species has a different method of gene expression for the enzyme. In Froggus goofus the Fatransformase protein is present at 10oC in the cells but is not active. In Froggus croakus the protein is not present at all. Indicate the level of regulation (name) that is occurring in each species and include/describe an example of what could be occurring at a molecular level.arrow_forwardSuppose that a mutation resulted in a tapeworm that did not have hooks. Assuming this tapeworm was a human parasite, what is the most likely explanation of the effect might this have? The tapeworm would spread throughout the human body. The tapeworm would complete its entire life cycle inside the human host. The tapeworm would not remain in the digestive tract very long. The tapeworm would not be able to enter the human body. The tapeworm would reproduce more to compensate for a lack of hooks.arrow_forwardRandom mutations only very rarely result in changes in a protein that improve its usefulness for the cell, yet useful mutations are selected in evolution. Because these changes are so rare, for each useful mutation there are innumerable mutations that lead to either no improvement or inactive proteins. Why, then, do cells not contain millions of proteins that are of no use?arrow_forward
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