You have been analyzing wing development mutants in Drosophila and have collected the genetic/Western data below. Your epistasis analysis (not shown), suggested your current model that DW-2 is upstream of WL-1. What is a plausible mechanism for how DW-2 regulates WL-1? mutant name wingless-1 doublewing-2 Probed with Ant-Wingless MW standards - mutanttype O DW-2 polyubiquitinates WL-1 null ODW-2 inhibits transcription of WL-1 null - phenotype O DW-2 phosphorylates WL-1 and prevents it from entering the nucleus DW-2 cleaves WL-1 proteolytically Model Ac Mode of regulation Wings DW-2 T Wings

Q: What would be the most likely effect on fruit-fly development of a deletion in the nanos gene?

A: Drosophila melanogaster is a fly species in the family Drosophilidae. This fly is commonly called as…

Q: Nanos is a strict maternal-effect gene in Drosophila; that is not transcribed in the embryo.…

A: The phenotypes of embryos with mutations in nanos can vary greatly, so it is important to predict…

Q: What would be the likely phenotypic effect of a mutation in HOTAIR and prevented it from binding to…

A: HOTAIR (HOX antisense intergenic RNA) is a long non-coding RNAs with 6 exons and 2158 nucleotides…

Q: In flies, the gap gene kruppel is expressed in a broad band in the middle of the embryo with giant…

A: Segmentation in Drosophila is a result of hierarchical and location specific expression of genes.…

Q: Mammals are anatomically and physiologically more complex than roundworms, yet both organisms have…

A: Pleiotropy is defined as the process where a single gene controls or influences the expression of…

Q: The CTCF protein is involved in the regulation of the Igf2-H19 gene cluster. Which of the following…

A: The gene expression involves transcription and later translation. Different mechanisms are involved…

Q: Mammals are anatomically and physiologically more complex than roundworms, yet both organisms have…

A: Pleiotropy is defined as the process where a single gene controls or influences the expression of…

Q: 12. a. You want to create a genetic construct that will express GFP in Drosophila. In addition to…

A: Since you have asked multiple questions, we will solve the first question for you. If you want any…

Q: How much more does cytokine 2 gene expression change in severe COVID-19 patients than in mild…

A: Cytokine storm is the condition when various cytokines are expressed in very high levels. This cause…

Q: In Drosophila the genes twist, snail, rhomboid and sog are expressed at differing positions along…

A: The DV axis in Drosophila refers to the dorsal-ventral polarity that is established during embryonic…

Q: Can I get a paragraph about the Repo protein that is used in Drosophila melangaster?

A: REPO (reverse polarity) is a paired-like homeodomain protein expressed in the glial cells of…

Q: Arabidopsis floral homeotic genes are members of the MADS box gene family, while homeotic genes in…

A:

Q: Propose a model that outlines, step-by-step, events that could reasonably generate the expression of…

A: The "Eve stripe protein" refers to a specific protein called "Even-skipped" (Eve) that is involved…

Q: Match each of the following categories of Drosophila developmental genes with the correct…

A: Genes are segments of DNA that contain the instructions for the development, function, and…

Q: Show how breeding females of the vermilion/brown, cinnabar/brown, and scarlet/brown double mutants…

A: In this answer below, we explore how breeding female mutants of the vermilion/brown, cinnabar/brown…

Q: The gain-of-function ANTP mutant in Drosophila has legs growing in the place of antennae. What is…

A: Hox genes are the genes which contain homebox sequence and these are responsible for the…

Q: What complications might arise from genetic screens targeting an organ that differentiates late in…

A: The eye has been one of the most intensively studied organs in Drosophila. The wealth of knowledge…

Q: Match the following transcription factors whose expression during embryonic development leads to the…

A: A. Late expression in the limb bud gives rise to autopod- Homeobox a13( hoxa13) The autopod…

Q: What phenotypes do you think a homozygous tra1hsn animal with a gain of function mutation in the…

A: Mutation changes genotype frequencies by continually implementing new alleles, that can be…

Q: If Gus is present in the Arabidopsis Thaliana what is it indicating? I know its to show gene…

A: Marker genes have a significant role in recombinant DNA technology-based transgenic plant production…

Q: Q1. (Shown below is the structure of a Drosophila gene, divided into 10 segments, designated A-J.…

A: The two steps of gene expression are transcription and translation. After transcription, the primary…

Q: The figure below shows the domains of expression of various maternal and gap genes as well as the…

A: A gap gene is a type of gene involved in the development of the segmented embryos of some…

Q: O A. Screen thousands of strains for a spontaneous unc-22 mutation O B. Soak worms in mutagenic…

A: In RNA silencing microorganisms are used to silence or negatively affect the gene expression. It is…

Q: What key features are required for an expression vector that would allow expression of a therapeutic…

A: In molecular biology, expression vector is a plasmid/viral vector for the expression of any…

Mitochondrial Mutations

A mitochondrion is a cellular organelle that serves as the site for cellular respiration and energy production (ATP or Adenosine Triphosphate). It is a double-membrane-bound organelle and is only present in eukaryotic cells.