You are doing experiments in a lab to test a potential new drug (you are calling it “relaxomere”) for the treatment of hypertension. You perform your initial experiments on a section of artery that you have removed from your laboratory rats. You are extremely excited
You are doing experiments in a lab to test a potential new drug (you are calling it “relaxomere”) for the treatment of hypertension. You perform your initial experiments on a section of artery that you have removed from your laboratory rats. You are extremely excited because placing your arterial prep in a bath containing relaxomere results in significant increases in diameter as a result of smooth muscle relaxation. However, when you attempt to produce the same relaxing affect in smooth muscle cells that you have isolated from your arterial prep you get absolutely no response. You are very depressed until you recall a mechanism discussed in physiology class that could explain this result. Completely describe this mechanism.
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