Without Inhibitor [substrate], mM Rate (Vo), mM/min 0.997774599 With Inhibitor Rate (Vo), mM/min 0.847401 1 1.5 1.076855826 0.973852 2 1.122873947 1.037991 2.5 1.160626292 1.068431 3 1.184072485 1.105866

Curren'S Math For Meds: Dosages & Sol
11th Edition
ISBN:9781305143531
Author:CURREN
Publisher:CURREN
Chapter6: Oral Medication Labels And Dosage Calculation
Section: Chapter Questions
Problem 2.7P
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PART IV. HOW FAST DOES IT GO?
Another member of your research group studied the kinetics of the
GAPDH from the organism. They also determined if the GAPDH from
the organism is also inhibited by the known inhibitor of GAPDH from
humans.

 

A. From the following data, determine the KM (Michaelis-Menten Constant) and the Vmax
(maximum velocity) of the enzyme without and with the inhibitor.

B. If GAPDH is inhibited, what specific type of inhibition is observed?

Without Inhibitor
[substrate], mM
Rate (Vo), mM/min
0.997774599
With Inhibitor
Rate (Vo), mM/min
0.847401
1
1.5
1.076855826
0.973852
2
1.122873947
1.037991
2.5
1.160626292
1.068431
3
1.184072485
1.105866
Transcribed Image Text:Without Inhibitor [substrate], mM Rate (Vo), mM/min 0.997774599 With Inhibitor Rate (Vo), mM/min 0.847401 1 1.5 1.076855826 0.973852 2 1.122873947 1.037991 2.5 1.160626292 1.068431 3 1.184072485 1.105866
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