Wilson's disease is an inherited disorder caused by a mutation in the ATP7B gene. Individuals lacking a functional ATP7B protein accumulate too much copper in the body's tissues. Above are pedigrees from two families of which some members have Wilson's disease (these are shaded black). Neither Hillary nor Foen has Wilson's disease. If they have a child together, what is the probability that this child will have Wilson's disease? 1/4 2/3 2/5 1/9 1 3/4 1/2 1/3 4/9 1/36 1/16
Wilson's disease is an inherited disorder caused by a mutation in the ATP7B gene. Individuals lacking a functional ATP7B protein accumulate too much copper in the body's tissues. Above are pedigrees from two families of which some members have Wilson's disease (these are shaded black). Neither Hillary nor Foen has Wilson's disease. If they have a child together, what is the probability that this child will have Wilson's disease?
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1/4 |
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2/3 |
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2/5 |
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1/9 |
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1 |
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3/4 |
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1/2 |
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1/3 |
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4/9 |
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1/36 |
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1/16 |
From the given pedigreees we can identify the mode of inheritance of Wilson's disease. In both families, the disease is inherited from unaffected parents. It indicates that both the families, the parents are heterozygous carriers for the disease and the disease is inherited as autosomal recessive manner.
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