WHICH OF THE FOLLOWING STATEMENTS IS CONSISTENT WITH THE RESULTS OF THE EXPERIMENT? Piericidin A inhibits ATP production of normal prostate epithelium. Piericidin only inhibits ATP production of normal prostate epithelium. Piericidin A stimulates ATP production of both normal and tumor-derived prostate epithelium. Piericidin A inhibits ATP production of both normal and tumor-derived prostate epithelium.
WHICH OF THE FOLLOWING STATEMENTS IS CONSISTENT WITH THE RESULTS OF THE EXPERIMENT? Piericidin A inhibits ATP production of normal prostate epithelium. Piericidin only inhibits ATP production of normal prostate epithelium. Piericidin A stimulates ATP production of both normal and tumor-derived prostate epithelium. Piericidin A inhibits ATP production of both normal and tumor-derived prostate epithelium.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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WHICH OF THE FOLLOWING STATEMENTS IS CONSISTENT WITH THE RESULTS OF THE EXPERIMENT?
Piericidin A inhibits ATP production of normal prostate epithelium.
Piericidin only inhibits ATP production of normal prostate epithelium.
Piericidin A stimulates ATP production of both normal and tumor-derived prostate epithelium.
Piericidin A inhibits ATP production of both normal and tumor-derived prostate epithelium.
Transcribed Image Text:Scientific evidence suggests that tumor cells, because they divide more rapidly than nontumor
cells, have increased energetic requirements. Investigators are curious about how the cellular
metabolic processes of cancer cells may be altered to meet these greater energetic demands.
In eukaryotic cells, the complete oxidation of glucose involves three processes: glycolysis in the
cytosol, and the Krebs cycle and electron transport in the mitochondria. The vast majority of
the useful cellular energy that is extracted from a glucose molecule (in the form of ATP) is
generated by the mitochondrial electron transport chain.
Researchers are interested in determining whether cancer cells rely more heavily on glycolysis
alone or on glycolysis and electron transport for their cellular energy. A reliance on one process
instead of another might suggest targeting that process as a potential therapy.
Normal prostate epithelial cells and tumor-derived prostate cells were cultured in normal
media (control), or media supplemented with the glycolytic inhibitor iodoacetate (IAA) or
Piericidin A. lodoacetate directly prevents the formation 1,3-bisphosphoglycerate, while
Piericidin A inhibits complex I of the mitochondrial electron transport chain. Cellular
production of ATP was measured and the results are given in the figure that follows.
tumor-derived prostate epithelium
normal prostate epithelium
Moles of ATP produced per minute
35
30
25
20
15
10
сл
5
0
control
w/IAA
w/Piericidin A
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