Which of the following effects would HELP hemoglobin BIND MORE oxygen in the lungs?
Which of the following effects would HELP hemoglobin BIND MORE oxygen in the lungs?
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Transcribed Image Text:Which of the following effects would HELP hemoglobin
BIND MORE oxygen in the lungs?
Question 11 options:
LOWER concentrations of BPG in red blood
cells of people living at sea level compared to
people living at hight altitude, because the
lower concentrations of BPG bind only to the T-
state and not the R-state. Lower amounts of
BPG would thus make it harder for Hb to adopt
the T-state and make it EASIER for Hb to adopt
the R-state and to bind oxygen more easily in
the lungs
Mutation of His-146 to Lys in the gene encoding
for the beta-subunit of hemoglobin would
introduce a positively charged amino group
over a wider range of pH, making it easier for
Hb to adopt the R-state and making it EASIER
for Hb to bind more oxygen in the lungs.
HIGHER pH in the lungs (reverse Bohr effect)
favours the deprotonation of His-146 in the
beta-chain of Hb, thus promoting the formation
of salt-bridges that stabilize the T-state but not
the R-state. This makes it EASIER for Hb to bind
more oxygen in the lungs.
LOWER concentrations of CO2 in the lungs
compared to in actively exercising muscle
tissues lead to LESS carbamylation of the
alpha-amino groups in Hb. This stabilizes the R-
state and makes it EASIER for Hb bind more
oxygen in the lungs.
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