When we compare DNA sequences among individuals, we tend to see lots or differences In non-coding regions of the genome but very few differences in coding regions, particullarly at second codon position in exons. What explains these different levels of nucleotide diversity?  A. Selection on coding regions B. Selection on non-coding regions C. Different mutation rates in coding and non-coding regions D. Protien folding patterns E. all the above

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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When we compare DNA sequences among individuals, we tend to see lots or differences In non-coding regions of the genome but very few differences in coding regions, particullarly at second codon position in exons. What explains these different levels of nucleotide diversity? 

A. Selection on coding regions

B. Selection on non-coding regions

C. Different mutation rates in coding and non-coding regions

D. Protien folding patterns

E. all the above

Expert Solution
Step 1

DNA, deoxy-ribonucleic acid, is made up of building blocks called nucleotides. Each nucleotide is made up of a phosphate group, a sugar group and one of four types of nitrogen bases. The four types of nitrogen bases found in nucleotides are: adenine (A), thymine (T), guanine (G) and cytosine (C). A nucleoside comprises the five-carbon sugar and nitrogenous base. Each nucleosides are bound together by phosphodiester bonds. DNA is a double stranded molecules, occurring in the helix fashion as proposed by Watson and Crick. The nitrogenous bases of each strand face each other antiparallelly and complementary nitrogen bases hydrogen bond to each other. The A-T pair forms two hydrogen bonds. The C-G pair forms three hydrogen bonds, thus stabilizing the DNA. 

 

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