When the production of acetyl-CoA exceeds the body’scapacity to oxidize it, acetoacetate, b-hydroxybutyrate, andacetone accumulate. When generated in large amounts, thesesubstances can exceed the blood’s buffering capacity. As theblood pH falls, the ability of red blood cells to carry oxygen isaffected. Subsequently, the brain can be starved for oxygen,and a fatal coma can result. Explain how severe dieting canproduce this condition.

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