What would happen to the H+ gradient if the inner mitochondrial membrane was perforated (punctured)?

Human Physiology: From Cells to Systems (MindTap Course List)
9th Edition
ISBN:9781285866932
Author:Lauralee Sherwood
Publisher:Lauralee Sherwood
Chapter2: Cell Physiology
Section: Chapter Questions
Problem 10RE: Using the answer code on the right, indicate which form of energy production is being described: 1....
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**Question:**
What would happen to the H+ gradient if the inner mitochondrial membrane was perforated (punctured)?

**Discussion:**
The inner mitochondrial membrane is crucial for maintaining the proton (H+) gradient that drives ATP synthesis during cellular respiration. If this membrane were perforated, it would disrupt the proton gradient established by the electron transport chain. Normally, protons are pumped from the mitochondrial matrix into the intermembrane space, creating a higher concentration of protons outside the inner membrane compared to the inside. This gradient represents potential energy used by ATP synthase to produce ATP.

A perforation in the inner mitochondrial membrane would allow protons to leak back into the mitochondrial matrix, bypassing ATP synthase. This would lead to a collapse of the proton gradient, severely affecting ATP production and potentially leading to cellular energy deficits.
Transcribed Image Text:**Question:** What would happen to the H+ gradient if the inner mitochondrial membrane was perforated (punctured)? **Discussion:** The inner mitochondrial membrane is crucial for maintaining the proton (H+) gradient that drives ATP synthesis during cellular respiration. If this membrane were perforated, it would disrupt the proton gradient established by the electron transport chain. Normally, protons are pumped from the mitochondrial matrix into the intermembrane space, creating a higher concentration of protons outside the inner membrane compared to the inside. This gradient represents potential energy used by ATP synthase to produce ATP. A perforation in the inner mitochondrial membrane would allow protons to leak back into the mitochondrial matrix, bypassing ATP synthase. This would lead to a collapse of the proton gradient, severely affecting ATP production and potentially leading to cellular energy deficits.
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