DNAWild-type Gene... GCC GAAVAlaProtein...Ala-CH3AGCV ↓GluSerGluFunctional enzymeWhat is the subject of the figure:HO-SerCatalyticsiteWhat is the main message of the figure?Mutant GeneGCC AAA AGC...✓✓ VAlaLysSerAla-CH₂Single nucleotide changeGive a concise, complete and specific explanation of the figure (happening at DNA, protein and enzyme layers shown.LysNH₂ HO-SerDefective enzymets)- Explain what is

Answered: What is the subject of the figure: What…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Related questions

Question

DNA
Wild-type Gene
... GCC GAA
V
Ala
Protein...
Ala-CH3
AGC
V ↓
Glu
Ser
Glu
Functional enzyme
What is the subject of the figure:
HO-Ser
Catalytic
site
What is the main message of the figure?
Mutant Gene
GCC AAA AGC...
✓
✓ V
Ala
Lys
Ser
Ala-CH₂
Single nucleotide change
Give a concise, complete and specific explanation of the figure (
happening at DNA, protein and enzyme layers shown.
Lys
NH₂ HO-Ser
Defective enzyme
ts)- Explain what is

Expert Solution

Step 1

Mutation is alteration in nucleic acid sequence of the gene which causes altered expression or up or down regulation of gene and eventually altered proteins. Mutated gene gives altered proteins which causes several types of genetic disorders. Mutation of gene can either leads to deletion, insertion, substitution and translocation. Mutation can be caused by (1) spontaneous mutations, (2) error-prone replication, (3) during DNA repair, and (4) by mutagens. Mutagens are chemical and physical agents which changes the gene sequence.