Creatine is a popular dietary supplement.**What is the biochemical rationale for the use of creatine?**- It would serve as an electron donor to support reductive biosyntheses required to sustain cellular function.- It would promote the movement of ions through ion channels and thus power the synthesis of ATP during exercise.- It would be converted into creatine phosphate and thus serve as a rapid means of replenishing ATP during muscle contraction.- It would directly serve as an electron carrier to support the oxidation of fuel molecules and thus energy production.**What type of exercise would benefit most from creatine supplementation?**- A long-distance run- A leisurely walk- Yoga- Sprinting

Creatine, or methyl guanidine-acetic acid, is endogenously formed and is a product of natural…

Answered: What is the biochemical rationale for…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Similar questions

Could you help propose a reasonable mechanism for the following biochemical transformation?
The following two reactions are coupled in the last step of glycolysis (catalyzed by the enzyme pyruvate kinase). РЕР + Н.О € Руr + Pi ADP + Pi → ATP + H2O AG° = -14.8 kcal/mol AG° = +7.3 kcal/mol D) The steady-state concentrations of ATP, ADP, and pyruvate in human erythrocytes are 2.24 mM, 0.25 mM, and 0.051 mM, respectively. What would be the concentration of PEP in these cells if the coupled reaction was at equilibrium?
Consider 3 molecules of galactose: (write only the whole number; no decimal places) How many turns of Krebs Cycle will these molecules undergo for complete oxidation? b. How many moles of ATP are produced upon complete oxidation via malate-aspartate shuttle? c. If all the galactose molecules oxidize via pentose phosphate pathway (oxidative stage only), how many moles of NADPH will be produced?
Two reactions are shown below. These reactions are directly coupled in cells by an enzyme called hexokinase, which is a key enzyme in glycolysis. It is generally the case that reactions that are directly coupled by enzymes share some common reactants. What is the net reaction when these two reactions are combined? Glucose + Inorganic Phosphate + ATP + Water → Glucose 6-phosphate + ADP Glucose + ATP + Water → Glucose 6-phosphate + ADP + Inorganic Phosphate Glucose + ATP → Glucose 6-phosphate + Inorganic Phosphate Glucose + ATP → Glucose 6-phosphate + ADP
How do the ligand (substrate) and the protein/enzyme predominantly interact? sigma bonds O Metallic bonds O Pi bonds O lonic bonds O Weak non-covalent bonds
In the PDH reaction alone, we can see cofactors that come from four different vitamins. What are they?
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With the aid of diagrams and equations, explain the biochemical processes involved in each of the following, in named cells. Start by mentioning the purpose and site of securrence of each. Go in details please. (a) Glucose-alanine cycle. (b) Oxidative phosphorylation.
Starting from glutamine + aspartate + glycine + CO + N-formyl-THF + ribose-5-P: How many ATP equivalents (GTP is an ATP equivalent) are required for the synthesis of the purine nucleotide ATP?
Prostaglandins are a group of lipid compounds having diverse hormone-like activities in animals. They are biosynthesized from the fatty acid arachidonic acid, catalyzed by the enzyme cyclooxygenase. The biosynthesis involves via a multistep radical mechanism. Can u show me in a stepwise mechanism how it is converted from radical intermediate A to prostaglandin PGG2.
Many years later, in 1989, Wild, et al. revisited the idea of allosteric control of ATCase by CTP. They noted that CTP did indeed inhibit ATCase, but that the inhibition was always incomplete, even at high concentrations of CTP. They hypothesized that perhaps CTP did not act alone, but in combination with some other nucleotide. They tested the activity of ATCase in the presence of several nucleotide combinations. The results are shown in Table 3. a. What combination gives the most effective inhibition? b. What is the physiological significance of this combination? c. Revise Figure 1 to include this new information. d. Redraw Figure 2 to include this new information. How does the combination compare with the values for the nucleotides alone? Table 3: Relative specific activities for combinations of nucleotide effectors. A value greater than one indicates stimulation, a value less than one indicates inhibition. Nucleotide Effector ATP CTP GTP UTP ATP/CTP ATP/GTP ATP/UTP CTP/GTP CTP/UTP…
Back in 1962, Gerhart and Pardee developed a model for the regulation of the activity of the ATCase enzyme by CTP and ATP, using the pathway given in Figure 1. Describe that model, using information presented here as well as what you have learned about allosteric enzymes. Be sure to include a sentence explaining the physiological significance of your model.

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