Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Transcribed Image Text:You are doing a genetic engineering experiment. You use restrictions enzymes to cut the regulatory
sequences from the lac operon and replace them with the regulatory sequences of the trp operon.
Specifically, you will eliminate everything upstream of the beginning of lacZ and replace them with
the trp sequences upstream of the beginning of trpE, including trpR. Now, describe the regulation of
your ñew constructed gene. What will you do to get expression of the three lac genes?
The lac Operon and its Control Elements
lacl
CAP P
lacz
lacY
lacA
genes
5
DNA
binding
site
3
AUG
AUG
AUG
messenger RNA
RNA polymerase blocked from
transcribing trp operon
Regulatory gene
trp operon
T
PR
Ptrp
DNA
trpR
trpE
trpD
trpC
trpB
trpA
Repressor bound
to operator
Promoter
5'
trpR-MRNA
R
(a) Tryptophan present, repressor bound to operator, operon repressed.
When complexed with tryptophan, the repressor protein produced by the
trpR gene binds tightly to the trp operator, thereby preventing RNA
polymerase from transcribing the operon genes.
Inactive form
Active form
T
of repressor
of repressor
Tryptophan
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