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Suppose a couple produces 2 children with Prader Willi Syndrome. The older child (Taylor) has two children with Prader Willi syndrome. The second child (Jordan) has one child with Angelman syndrome. A. What are the two genders of Taylor and Jordan (and how do you know)? B. Are their parents phenotypically normal? Do you know which parent carries a mutation?

Suppose a couple produces 2 children with Prader Willi Syndrome. The older child (Taylor) has two children with Prader Willi syndrome. The second child (Jordan) has one child with Angelman syndrome. A. What are the two genders of Taylor and Jordan (and how do you know)? B. Are their parents phenotypically normal? Do you know which parent carries a mutation?

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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**Transcription of Prader-Willi and Angelman Syndrome Exercise** Suppose a couple produces two children with Prader-Willi Syndrome. The older child (Taylor) has two children with Prader-Willi syndrome. The second child (Jordan) has one child with Angelman syndrome. **A. What are the two genders of Taylor and Jordan (and how do you know)?** **B. Are their parents phenotypically normal? Do you know which parent carries a mutation?** **Analysis and Explanation:** - **Prader-Willi Syndrome (PWS)** is typically due to the absence of a paternal copy of genes on chromosome 15 (15q11-q13). - **Angelman Syndrome (AS)** results from the absence of a maternal copy of genes in the same region (15q11-q13). **Answer to A:** Taylor must be male because Prader-Willi Syndrome in Taylor's children suggests the deletion or imprinting defect came from Taylor himself. Jordan must be female as she has a child with Angelman syndrome, which suggests the maternal copy was affected. **Answer to B:** The parents are likely phenotypically normal due to a mechanism such as balanced translocation or imprinting center defect, which doesn't necessarily affect carriers visibly but can affect offspring. The father is likely carrying the mutation affecting chromosome 15 that leads to PWS when passed paternally and AS when passed maternally through the children.
Transcribed Image Text:**Transcription of Prader-Willi and Angelman Syndrome Exercise** Suppose a couple produces two children with Prader-Willi Syndrome. The older child (Taylor) has two children with Prader-Willi syndrome. The second child (Jordan) has one child with Angelman syndrome. **A. What are the two genders of Taylor and Jordan (and how do you know)?** **B. Are their parents phenotypically normal? Do you know which parent carries a mutation?** **Analysis and Explanation:** - **Prader-Willi Syndrome (PWS)** is typically due to the absence of a paternal copy of genes on chromosome 15 (15q11-q13). - **Angelman Syndrome (AS)** results from the absence of a maternal copy of genes in the same region (15q11-q13). **Answer to A:** Taylor must be male because Prader-Willi Syndrome in Taylor's children suggests the deletion or imprinting defect came from Taylor himself. Jordan must be female as she has a child with Angelman syndrome, which suggests the maternal copy was affected. **Answer to B:** The parents are likely phenotypically normal due to a mechanism such as balanced translocation or imprinting center defect, which doesn't necessarily affect carriers visibly but can affect offspring. The father is likely carrying the mutation affecting chromosome 15 that leads to PWS when passed paternally and AS when passed maternally through the children.
Expert Solution
Introduction

Prader-Willi Syndrome and Angelman Syndrome are inheritable genetic disorders caused by gene deletion of Chromosome 15.  Both Disorders involve similar phenomena called "imprinting" in which either the maternal or paternal chromosome is inactivated for normal fetal development.

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