Use curve arrows to show the mechanism for theproposed conversion of 2a, 2b, 2c, and 2d to 4.Based on the evidence presented, which is the mostlikely pathway?Explain the rationale for your choice.Scheme 1HНоHNH+02 + 2 H+ + 2 e-+ H20ÖH* H,O12a3wwhm = a nucleophilic site on glutathione/cellular proteinScheme 2HN+ H,OH+02 + 2 H++ NADPH+H,0 + NADP2b3mhm = a nucleophilic site on glutathione/cellular proteinScheme 3Bio.BioHBioHBio•20HNX.3Bio•HRioHN.4O: Scheme 2HN+ H20H+02 + 2 H++ NADPHHO+H20 + NADP2b3mhm = a nucleophilic site on glutathione/cellular proteinScheme 3Bio:BioHBioHBio•20HN3Bio•BioH4OHBioH1Bio•2dBio = a biological molecule with a radical moiety such as heme, an Fe" containing coenzyme.wwm =a nucleophilic site on glutathione/cellular proteinO:

Answered: Image /qna-images/answer/74e005dd-c8f3-484c-91e9-906f5161a576.jpg

Answered: Use curve arrows to show the mechanism…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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a) The table above shows the predicted results. A plus means when the strain with a mutation in the enzyme on the left is given radiolabeled A then radiolabel can be detected in the intermediate at the top. Are all the predicted results correct? yes no b) If you answered yes for part a, explain the results for row 3 (3 sentences MAX); if you answered no, state which boxes are wrong. c) Under what cellular conditions would you expect this pathway to be fully inhibited? (1 sentence Max) d) The upper branch (leading to F) is a pathway that is breaking down a metabolite to make ATP and the middle pathway uses ATP to synthesize I. How would you expect the following enzymes to be regulated by energy charge? Enzyme 1: Enzyme 4: Enzyme 6:
Which parameters are plotted on the X and Y axes of a Kaplan-Meier graph?
You have created three different mutations in the histoneH1 protein (HISmut1, HISmut2, HISmut3), and each of these mutations eliminate a stretch of 5 amino acids from the primary sequence. Based on the description of where you find the mutant histoneH1 proteins when you look inside a cell in each of the cases below, describe 1) what the function is of the amino acids that were removed, and 2) what is not happening with the mutant histoneH1 protein that does happen with wild type H1: 1. HISmut2 protein is found in the cytoplasm, and never in the nucleus. 2. HISmut1 protein is found in only briefly in the cytoplasm because it is very quickly sent to the proteasome. 3. HISmut3 protein is found floating freely throughout the nucleoplasm.
5.) You have identified a mutant with the following phenotype: a) Explain what has most likely happened to the chromatin in the mutant fly. b) Which enzyme do you think has undergone a mutation in your mutant fly? There is more than one correct answer, just give one possibility. c) How did the mutation in the enzyme you identified in part b affect the activity of that enzyme in order to see the phenotype we observed above?
You have isolated 8 mutants in yeast that fail to grow on minimal media plates but do grow when they are supplemented with Arginine. You know that Arginine is synthesized in a biochemical pathway within wild-type yeast, but you do not know how many gene products it takes for the pathway. You have all of the lines as both a and a cells and mate each strain to each other in pairwise crosses and plate them on minimal media to see if they grow. You obtain the following results with (+) representing growth, and (-) indicating no growth: a 1 5 1 a 4 5 6 7 8 How many genes are represented? O 1 3 7 O Cannot tell from the data a + + + + + • + + i 0 +, + + + • + + 7 + + + + + , . + + + + + m + + + + + + + 2 + + + + + i + -I + + . . + + +
Based on one strand of a certain segment of DNA with the sequence below, answer the following question: 3'-ATGGATCCCATC-5' a. Is the formula "genotype + environment=phenotype" accurate?
The map shows a wild-type HOAP gene, whereas Mutant 1 has a DNA deletion from base pair 1125 to 1445 and Mutant 2 contains a point mutation at 1372. Predict the sizes of DNA fragments that would be generated in each of the following digests. Wild-type (BamHI): Wild-type (EcoRI): Wild-type (BamHI + EcoRI): Mutant 1 (BamHI): Mutant 1 (EcoRI): Mutant 1 (BamHI + EcoRI): Mutant 2 (BamHI): Mutant 2 (EcoRI): Mutant 2 (BamHI + EcoRI): BamHI O EcoRI 740 Promoter ECORI 1140 HOAP HOAP HP1/ORC Associated Protein 7200 bp Sacl 2100 BamHI 2420 Psti 2700 Hindlll 3440
1) Using the diagram below, sketch in the pattern of bands you would expect to see after digesting the DNA of the TT, Tt and tt genotypes of the TAS2R38 gene. Use the Base Pair Standards on the left of the diagram as a reference in drawing the positions of the bands. Base Pair TASTER GENO TYPE Standards (Base Pairs) TT Tt tt 500 400 300 200 100 50
What is the correct answer, and why?
Which of the following mutations is likely to cause the most dramatic mutant effects: Missense, nonsense, sense? Explain your answer.
Match the pictures of the small-scale chromosome changes to the terms. A) translocation B) deletion C) inversion D) duplication
A 19 year old female patient is diagnosed with chronic myelogenous leukemia. Karyotype analysis shows that the leukemic cells of this patient are heterozygous for a reciprocal translocation involving chromosomes 9 and 22. However, none of the normal, nonleukemic cells of this patient contain the translocation. a) Describe a molecular test to determine if chemotherapy given to the patient described would be completely succesful. (That is, devise a method to make sure that the patient's blood would be free of leukemic cells.) Be as specific as possible.

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Use curve arrows to show the mechanism for the proposed conversion of 2a, 2b, 2c, and 2d to 4.