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Unlike dopamine, levodopa can cross the blood brain barrier (B8B). Which of the following statements best describes the reasoning но. NH2 но. CHO. NH2 но но Dopamine (log P 0.85) Levodopa (log P-0.22) The physicochemical properties of levodopa and its partial facilitated transport by neutral amino acid transporters can explain the ability of levodopa to cross the BB The lower partition coefficient (log P) of levodopa indicates the molecule is more hydrophobic than dopamine, and therefore better able to cross the B88 Unlike dopamine, levodopa is not metabolized in the periphery, and therefore more circulating drug is available for transport across the BBB. Levodopa itself cannot cross the BBB, and must be coadministered with carbidopa, which enables its BB8 transport.

Unlike dopamine, levodopa can cross the blood brain barrier (B8B). Which of the following statements best describes the reasoning но. NH2 но. CHO. NH2 но но Dopamine (log P 0.85) Levodopa (log P-0.22) The physicochemical properties of levodopa and its partial facilitated transport by neutral amino acid transporters can explain the ability of levodopa to cross the BB The lower partition coefficient (log P) of levodopa indicates the molecule is more hydrophobic than dopamine, and therefore better able to cross the B88 Unlike dopamine, levodopa is not metabolized in the periphery, and therefore more circulating drug is available for transport across the BBB. Levodopa itself cannot cross the BBB, and must be coadministered with carbidopa, which enables its BB8 transport.

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Unlike dopamine, levodopa can cross the blood brain barrier (BBB). Which of the following statements best describes the reasoning Donm sond но. NH2 но, HO. NH2 но но Dopamine (log P 0.85) Levodopa (log P-0.22) The physicochemical properties of levodopa and its partial facilitated transport by neutral amino acid transporters can explain the ability of levodopa to cross the BBB The lower partition coefficient (log P) of levodopa indicates the molecule is more hydrophobic than dopamine, and therefore better able to cross the B88 Unlike dopamine, levodopa is not metabolized in the periphery, and therefore more circulating drug is avallable for transport across the BBB. OLevodopa itself cannot cross the BBB, and must be coadministered with carbidopa, which enables its BBB transport. Moving to another question will save this response.
Transcribed Image Text:Unlike dopamine, levodopa can cross the blood brain barrier (BBB). Which of the following statements best describes the reasoning Donm sond но. NH2 но, HO. NH2 но но Dopamine (log P 0.85) Levodopa (log P-0.22) The physicochemical properties of levodopa and its partial facilitated transport by neutral amino acid transporters can explain the ability of levodopa to cross the BBB The lower partition coefficient (log P) of levodopa indicates the molecule is more hydrophobic than dopamine, and therefore better able to cross the B88 Unlike dopamine, levodopa is not metabolized in the periphery, and therefore more circulating drug is avallable for transport across the BBB. OLevodopa itself cannot cross the BBB, and must be coadministered with carbidopa, which enables its BBB transport. Moving to another question will save this response.
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