Two circular DNA molecules, which we can call molecule A andmolecule B, are topoisomers of each other. When viewed under theelectron microscope, molecule A appears more compact than molecule B. The level of gene transcription is much lower for molecule A. Which of the following three possibilities could accountfor these observations?First possibility: Molecule A has three positive supercoils, andmolecule B has three negative supercoils.Second possibility: Molecule A has four positive supercoils, andmolecule B has one negative supercoil.Third possibility: Molecule A has zero supercoils, and molecule Bhas three negative supercoils.

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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Two circular DNA molecules, which we can call molecule A and
molecule B, are topoisomers of each other. When viewed under the
electron microscope, molecule A appears more compact than molecule B. The level of gene transcription is much lower for molecule A. Which of the following three possibilities could account
for these observations?
First possibility: Molecule A has three positive supercoils, and
molecule B has three negative supercoils.
Second possibility: Molecule A has four positive supercoils, and
molecule B has one negative supercoil.
Third possibility: Molecule A has zero supercoils, and molecule B
has three negative supercoils.

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