Two adjacent thymidine residues in DNA can dimerize in the presence of UV light to form thymine dimers. The reaction occurs via a [2+2] cycloaddition reaction. Thymine dimers can be repaired by DNA repair enzymes. However, DNA repair enzymes occasionally make mistakes which lead to mutations and eventually skin cancer. There are two [2+2] cycloaddition reactions that can occur between two thymidine residues. detailed mechanisms for both. (HINT: One of them has a heterocyclic ring intermediate.) Draw Me HN N. R Figure 1: thymidine residue. R - sugar phosphate backbone of DNA

Two adjacent thymidine residues in DNA can dimerize in the presence of UV light to form thymine dimers. The reaction occurs via a [2+2] cycloaddition reaction. Thymine dimers can be repaired by DNA repair enzymes. However, DNA repair enzymes occasionally make mistakes which lead to mutations and eventually skin cancer. There are two [2+2] cycloaddition reactions that can occur between two thymidine residues. detailed mechanisms for both. (HINT: One of them has a heterocyclic ring intermediate.) Draw Me HN N. R Figure 1: thymidine residue. R - sugar phosphate backbone of DNA

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

See similar textbooks

Similar questions

alpha helix at PH35? Provide 3 reasons to justify your answer. 4. Fructose and caproic acid are both molecules that contain a 6 carbon backbone. The melting point of fructose is 103°C and the melting point of caproic acid is 31.6°C. Explain why the melting points for the two molecules differ so drastically. The structures for these two molecules are provided below. он Fructose CH,OH O Caproic acid H. но CH,OH CH3(CH2)3CH2 HOH он H. 24
please answer asap Based on the nucleotide structure below, which of the following is correct about the nucleotide shown? The atoms are color codded: carbon is in green, nitrogen is in blue, oxygen is in red, and phosphorus is in pink.
The interaction of many different protein factors to stimulate or repress transcription forms a complex called: combinatorial control synergy ALL OF THESE mediator. NONE OF THESE
Please draw and give the name of the product. Thank you!
Many peptides react further after synthesis (process is called post-translational modification). In this example a cysteine cyclizes to form a thiazole ring in Sanguinamide A. O= HN HN" SH -H₂O o= HN" 0= 0= N₂ S HN Sanguinamide A
Please help me!
Draw the dinucleotide dApdG (shown above). Draw a dinucleotide that you would expect to hydrogen bond most stably to dApdG. Include every atom and every ring atom number, every charge, correct orientation of the base and the backbone linkages with respect to the ribose ring, the number of angstroms between N’s and O’s involved in the hydrogen bonds, and the number of angstroms between the riboses involved as support for each base in the hydrogen bonded pair.
Of the four DNA bases, why is guanine most likely to be modified after exposure to polycyclic hydrocarbons such as benzo(a)pyrene, as shown in Figure ? (Hint: Consider the pKa values of the four DNA bases.)
Give detailed Solution with explanation needed..Give correct answer
17 - Tuzak destekli rekombinasyonun diğer adı nedir?What’s the other name of trap-assisted recombination? A) Delgi rekombinasyonu Auger Recombination B) Yüzey rekombinasyonu Surface Recombination C) Shockley-Read-Hall Shockley-Read-Hall D) Langevin rekombinasyonu Langevin Recombination E) Elektron recombinasyonu Electron Recombination
Compare the two peptides shown below, which can be ordered from chemical supply companies: Time left 0:58:26 H₂N NH OH O b. O c. NH. CH3 Which statement is correct about these peptides? OH Peptide A Peptide B O a. Peptide A can only be in an alpha helix and cannot form a beta-strand; Peptide B can be in alpha helix or beta strand Peptide B will have a higher absorbance at 280nm because it is shorter in length Peptide A will have a higher absorbance at 280nm because it has more aromatic amino acids O d. Both peptide A and peptide B lack any acidic amino acids
I am not sure how to do number 10