TRUE OR FALSE 1. Nitrogenous bases cannot undergo electrophilic aromatic substitution. 2. Cytosine forms three hydrogen bonds with guanine while Adenine forms two hydrogen bonds with Thymine in the messenger RNA. 3. The glycosidic bond in nucleotides is stable in dilute ammonium hydroxide solution and dilute Sodium bicarbonate solution. 4. In gel electrophoresis, a DNA is expected to migrate towards the cathode. 5. Tautomerism is a phenomenon observed in both purine and pyrimidine bases.

TRUE OR FALSE 1. Nitrogenous bases cannot undergo electrophilic aromatic substitution. 2. Cytosine forms three hydrogen bonds with guanine while Adenine forms two hydrogen bonds with Thymine in the messenger RNA. 3. The glycosidic bond in nucleotides is stable in dilute ammonium hydroxide solution and dilute Sodium bicarbonate solution. 4. In gel electrophoresis, a DNA is expected to migrate towards the cathode. 5. Tautomerism is a phenomenon observed in both purine and pyrimidine bases.

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter8: The Structure, Replication, And Chromosomal Organization Of Dna

Section: Chapter Questions

Problem 15QP: Using Figures 8.7 and 8.9 as a guide, draw a dinucleotide composed of C and A. Next to this, draw...

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N. NH 2. One of the key pieces of information that Watson and Crick used in determining the secondary structure of DNA came from experiments done by E. Chargaff, in which he studied the nucleotide composition of DNA from many different species. O=P-OCH, N. `NH, HN он O= P- OCH, NH, Chargaff noted that the molar quantity of A_was always approximately equal to the molar quantity of T. and the molar quantity of C was always approximately equal to the molar quantity of G. How were Chargaff's results explained by the structural model of DNA proposed by Watson and Crick? N OH N. O= P-OCH, OH OH
True or False, if the statement is false, provide the correct answer. 1. The amino acid sequence is not responsible for specifying the 3D shape of a protein. 2. The red, orange, and yellow pigments found in plants, that are often visible in the fall are chlorophyll. 3. There are 10 base pairs in one full turn of the DNA double helix. 4. The stroma is a gel-like material within the chloroplast that corresponds to the cytoplasm of the original bacterium. 5. Plants gather the sun's energy with light-absorbing molecules called pigments.
P2. Calculate the frictional coefficient of a molecule of DNA of 20 base pairs in water at 20C; assume that the hydrodynamic behavior of the DNA itself can be approximated to be rod-like; the viscosity of the solvent is 0.01 g cm-1 s -1
TRUE OR FALSE] 11. The structure of the DNA, being super coiled, promotes increased viscosity of the molecule.12. The stacking position of the nitrogenous bases is caused by intramolecular Van der Waals Interaction.13. The histone complex is a quaternary protein structure.14. The difference between ribose and deoxyribose is in the presence of oxygen in carbon number 3 of the sugar moiety.15. The sedimentation coefficient of the nucleic acid is higher compared to ribosomes.
9. (a) Q1 a. Justify why the base thyamine is prefered over guanine in DNA while the reverse is preferred in RNA. Provide the chemistry involved to support your answer.
Consider normal B-form DNA. It forms a regular antiparallel double-helical structure with Watson-Crick base-pairing mediated through hydrogen bonding. The base pairs all stack upon one another, with 3.4 Å spacing between them. DNA strands having a complementary sequence will spontaneously form a double-helix in an aqueous solution. In terms of energy, what primarily drives helix formation? O Positive Entropy from base stacking van der Waals interactions O Hoogsteen interactions Positive Enthalpy from Hydrogen Bonding between GC and AT pairs Negative Enthalpy from Hydrogen Bonding between GC and AT pairs O Negative Entropy from base stacking
Show the separation pattern of the following DNA molecules on 1 % agarose gel. Justify your results. 5 kbp 5 kbp 5 kbp 5 kb +
You have an aqueous solution containing: Alaine (a mono-amino, monocarboxylic acid) Fructose (a non-ionic monosaccharide) Glycogen (a non-ionic large polysaccharide) Ribose-5-phosphate (an anionic monosaccharide phosphate) t-RNA (a polyanionic nucleic acid, MW~ 30,000). Assuming you have a distinctive assay for each of these compounds, what procedures would you use to obtain gram quantities of each of these compounds free of each of the other compounds
Using Figures 8.7 and 8.9 as a guide, draw a dinucleotide composed of C and A. Next to this, draw the complementary dinucleotide in an antiparallel fashion. Connect the dinucleotides with the appropriate hydrogen bonds. FIGURE 8.9 The two polynucleotide chains in DNA run in opposite directions. The left strand runs 5 to 3, and the right strand runs 3 to 5. The base sequences in each strand are complementary. An A in one strand pairs with a T in the other strand, and a C in one strand is paired with a G in the opposite strand. FIGURE 8.7 Nucleotides can be joined together to form chains caled polynucleotides. Polynucleotides are polar molecules with a 5 end (at the phosphate group) and a 3 end (at the sugar group). An RNA polynucleotide is shown at the left, and a DNA polynucleotide is shown at the right.
10.) Draw a double-stranded DNA molecule (using different colors for each) model should clearly represent the sequence: A G T A C C G G G C A A Note: It should include items to represent - sugar molecules - phosphate molecules - 4 distinct nitrogenous base molecules (Adenine, Thymine, Cytosine, and Guanine) - two types of bonds between these molecules
20. Nucleosides consist of a nitrogenous base bound by an N-glycosyl linkage to a phosphorylated pentose. true or false
37. Which nucleotide can be found in DNA? Group of answer choices deoxyribose + phosphate group + thymine ribose + phosphate group + uracil deoxyribose + phosphate group + uracil ribose + phosphate group + thymine