Transepidermal water loss (TEWL) is a measure of the rate that water crosses the skin through diffusion and evaporation. In general, damaged skin has a higher TEWL than nondamaged skin. A report submitted to the U.S. Food and Drug Administration (Therapeutic Equivalence of Topical Products, A. Bunge, B. N'Dri-Stempfer, et al., 2007) described an experiment in which the outer layer of skin on a small area of the foream was partially removed in order to measure the concentration of a certain drug. TEWL (in g/m? per hour) was measured both before and after skin removal. The results for 10 individuals were as follows. Subject Before After 18 27 2 12 19 3 14 19 4 11 20 5 12 22 17 26 16 18 8 18 26 14 22 10 14 24 Find a 98% confidence for the increase in TEWL.

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Transepidermal water loss (TEWL) is a measure of the rate that water crosses the skin
through diffusion and evaporation. In general, damaged skin has a higher TEWL than
nondamaged skin. A report submitted to the U.S. Food and Drug Administration
(Therapeutic Equivalence of Topical Products, A. Bunge, B. N'Dri-Stempfer, et
al., 2007) described an experiment in which the outer layer of skin on a small area of the
foream was partially removed in order to measure the concentration of a certain drug.
TEWL (in g/m? per hour) was measured both before and after skin removal. The results for
10 individuals were as follows.
Subject
Before
After
18
27
2
12
19
3
14
19
4
11
20
5
12
22
17
26
16
18
8
18
26
14
22
10
14
24
Find a 98% confidence for the increase in TEWL.
Transcribed Image Text:Transepidermal water loss (TEWL) is a measure of the rate that water crosses the skin through diffusion and evaporation. In general, damaged skin has a higher TEWL than nondamaged skin. A report submitted to the U.S. Food and Drug Administration (Therapeutic Equivalence of Topical Products, A. Bunge, B. N'Dri-Stempfer, et al., 2007) described an experiment in which the outer layer of skin on a small area of the foream was partially removed in order to measure the concentration of a certain drug. TEWL (in g/m? per hour) was measured both before and after skin removal. The results for 10 individuals were as follows. Subject Before After 18 27 2 12 19 3 14 19 4 11 20 5 12 22 17 26 16 18 8 18 26 14 22 10 14 24 Find a 98% confidence for the increase in TEWL.
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