The top side of this figure offers more opportunities (for each base pair) that can lead to highly specific protein-DNA interactions. True or False?Major grooveMajor groove(a) Major grooveMajor grooveO TrueN-HI110O FalseA NIIH-NMinor grooveAdenine-ThymineCH30111H-NH₂C OFITH98TN-GN-HIINV-HillOMinor grooveGuanine CytosineMinor grooveThymine-AdenineHilloC NIHOIH-NGMinor grooveCytosine Guanine

A single stranded nucleic acid is formed by joining the nucleotide units together through…

Answered: The top side of this figure offers more…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Similar questions

Describe the d=features of the following DNA-binding domains and how they interact with DNA. Helix-turn-Helix Zinc Finger Leucine Zipper Helix-loop-Helix
In chromosomes, doubly-stranded DNA wraps tightly around histone proteins. Think about the structure of DNA, especially the "backbone," and determine what category of amino acids make up the majority of histones: Histone Octamer tetramer dimer HZA dimer dimer dimer Histone "fastener" Here the blue represents histones, and the red is the DNA strand. To help the DNA fold up in an aqueous environment, the histones are nonpolar to exclude water, so many of the amino acid side chains are nonpolar. The backbone of DNA is the alternating phosphate-sugar part, and the phosphate is negatively charged. Positive charges on the histone residues will bind tightly here, so the acidic amino acids are used here. The backbone of DNA is the alternating phosphate-deoxyribose part, and the phosphate is negatively charged. Positive charges on the histone residues will bind tightly here, so the basic amino acids are used here. The histones are strongly attracted to the hydrogen-bonding of the base pairs, so…
Give the mRNA and amino acid sequence from this DNA strand: TACATACCTCGGCTTTGGCTGAAAGGTACTTATAATGCT
Draw and label the following RNA tetranucleotide: 5’phosphoryl-A-2’O-methyl-C-U-G-3’-phosphate
Which of the following molecules is a nitrogen base that would be found in 1 po DNA? (check all that apply) * Adenine Guanine Uracil Baycil Thymine Qualine Cytosine Lenovo esc -> @ # 2 7 8. tab W e r y u i d f g. k a S 31 C V alt alt ctri .... V -
What is the conformation of the glycosidic bond (i.e. orientation of the nucleobase relative to the the sugar) in the B-form of DNA? syn anti alpha hetero
Hydrolysis of the N-glycosyl bond between deoxyribose and a purine base in DNA creates an apurinic (AP) site. An AP site is more thermodynamically destabilizing to a DNA molecule than is a mismatched base pair. Examine the structure of an AP site. H₂N HN N O™ -O-P-O-CH₂ Guanine H₂N N HN Select the chemical consequences that could contribute to DNA instability at AP sites. H H 1₂0/ H fewer hydrogen bonds between the unpaired pyrimidine base and water disruption of the base-stacking interactions decreased interaction between the mutated DNA strand and histones increased ability of the deoxyribose ring to open without the attachment of the purine base H H Guanosine residue (in DNA) O™ -O-P-O-CH₂ O H H H O Apurinic residue H OH H
Write the base sequence and label the 3' and 5' ends of the complementary strand for a segment of DNA with the following base sequences: 5'CGGAC3'
A polypeptide is digested with trypsin, and the resulting segments are sequenced: Val-Gly Ala-Ala-Gly-Leu-Trp-Arg Arg-Asp-Pro-Gly-Lue-Met-Val-Leu-Tyr-Ala-Ala-Asp-Glu-Lys And the following fragments are produced by chymotrypsin fragmentation: Ala-Ala-Gly-Leu-Trp Arg-Arg-Asp-Pro-Gly-Leu- Met-Val-Leu-Tyr Ala-Ala-Asp-Glu-Lys-Val-Gly What is the sequence of the whole original polypeptide? (Recall that trypsin cleaves a polypeptide backbone at the C-terminal side of Arg or Lys residues, whereas chymotrypsin cleaves after aromatic amino acid residues).
Consider normal B-form DNA. It forms a regular antiparallel double-helical structure with Watson-Crick base-pairing mediated through hydrogen bonding. The base pairs all stack upon one another, with 3.4 Å spacing between them. DNA strands having a complementary sequence will spontaneously form a double-helix in an aqueous solution. In terms of energy, what primarily drives helix formation? O Positive Entropy from base stacking van der Waals interactions O Hoogsteen interactions Positive Enthalpy from Hydrogen Bonding between GC and AT pairs Negative Enthalpy from Hydrogen Bonding between GC and AT pairs O Negative Entropy from base stacking
Write the complementary strand to the following single-stranded DNA and label the 5' and 3' ends: 5'-ATAGCATGGGCCATACGATTACTGA-3'
In Figure 1-8b, can you tell if the number of hydrogenbonds between adenine and thymine is the same as thatbetween cytosine and guanine? Do you think that aDNA molecule with a high content of A + T would bemore stable than one with high content of G + C?

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