The Stanford University Heart Transplant Study was conducted to determine whether an experimental heart transplant program increased lifespan. Each patient entering the program was officially designated a heart transplant candidate, meaning that he was gravely ill and might benefit from a new heart. Patients were randomly assigned into treatment and control groups. Patients in the treatment group received a transplant, and those in the control group did not. The table below displays how many patients survived and died in each group   ___ control______treatment___ alive 4 | 24   dead 30 | 45   A hypothesis test would reject the conclusion that the survival rate is the same in each group, and so we might like to calculate a confidence interval. Explain why we cannot construct such an interval using the normal approximation. What might go wrong if we constructed the confidence interval despite this problem?

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The Stanford University Heart Transplant Study was conducted to determine whether an experimental heart transplant program increased lifespan. Each patient entering the program was officially designated a heart transplant candidate, meaning that he was gravely ill and might benefit from a new heart. Patients were randomly assigned into treatment and control groups. Patients in the treatment group received a transplant, and those in the control group did not. The table below displays how many patients survived and died in each group

 

___ control______treatment___

alive 4 | 24

 

dead 30 | 45

 

A hypothesis test would reject the conclusion that the survival rate is the same in each group,

and so we might like to calculate a confidence interval. Explain why we cannot construct such an

interval using the normal approximation. What might go wrong if we constructed the confidence interval despite this problem?

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