The second messenger cyclic AMP (CAMP) is synthesized from ATP by the activity of the enzyme adenylyl cyclase. Cyclic AMP, in turn, activates protein kinase A (PKA), also called cAMP-dependent protein kinase, which is responsible for most of the effects of CAMP within the cell. Determine the correct steps in the activation of PKA, and then place them in the correct order, starting after the adenylyl cyclase reaction. Cytosolic CAMP concentration increases. Two cAMP molecules bind to each PKA regulatory subunit. Each regulatory subunit is activated as the two CAMP molecules release. The regulatory subunits dissociate from the catalytic subunits. Answer Bank Cytosolic CAMP concentration decreases. The free catalytic subunits interact with proteins to phosphorylate Ser or Thr residues.

The second messenger cyclic AMP (CAMP) is synthesized from ATP by the activity of the enzyme adenylyl cyclase. Cyclic AMP, in turn, activates protein kinase A (PKA), also called cAMP-dependent protein kinase, which is responsible for most of the effects of CAMP within the cell. Determine the correct steps in the activation of PKA, and then place them in the correct order, starting after the adenylyl cyclase reaction. Cytosolic CAMP concentration increases. Two cAMP molecules bind to each PKA regulatory subunit. Each regulatory subunit is activated as the two CAMP molecules release. The regulatory subunits dissociate from the catalytic subunits. Answer Bank Cytosolic CAMP concentration decreases. The free catalytic subunits interact with proteins to phosphorylate Ser or Thr residues.

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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