Question 11B.1.351 is a variant of SARS-CoV-2. It has the amino acid substitution N501Y in the spike proteinon the virus surface. In cellular fluids at -pH 7 the wild type spike protein has a net negativecharge. This substitution will make the spike proteinO more negativeO less hydrophobicO less negativeO absorb more UV lightPlease provide explanation, thank you!

The aromatic amino acids like Tyrosine, tryptophan and phenylalanine absorb ultraviolet light. The…

Answered: B.1.351 is a variant of SARS-CoV-2. It…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Please help me with this question. More than one answer may be correct. The graph relating to the information is included below. The above graph is looking at the relative entry of SARS-CoV2 isolated spike proteins into human cells in culture at two times points: before introduction of the virus to the cell culture (0 minute) and 5 minutes after introduction of the virus to the cell culture. CHC stands for "clathrin heavy chain" and siRNA stands for small interfering RNA, which is often used in experiments as an easy method to stop expression of a certain gene. So in this case, the CHC siRNA would stop cellular production of CHC. The control siRNA introduces a small RNA fragment that does not match any gene as a negative control. Imagine that the experiment was then allowed to run for 500 minutes in addition to five minutes? How would the relative uptake of the spike protein into the control siRNA cells compare after 500 min to the 5 minute treatment? Options: 500 min time point would…
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